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EC 1.3.8.7 Details
EC number
1.3.8.7
Accepted name
medium-chain acyl-CoA dehydrogenase
Reaction
a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Other name(s)
fatty acyl coenzyme A dehydrogenase (ambiguous),
acyl coenzyme A dehydrogenase (ambiguous),
acyl dehydrogenase (ambiguous),
fatty-acyl-CoA dehydrogenase (ambiguous),
acyl CoA dehydrogenase (ambiguous),
general acyl CoA dehydrogenase (ambiguous),
medium-chain acyl-coenzyme A dehydrogenase,
acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous),
ACADM (gene name).
Systematic name
medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.7
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