Information on EC - long-chain acyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.8
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IUBMB Comments
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively . The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 . cf. EC, short-chain acyl-CoA dehydrogenase, EC, medium-chain acyl-CoA dehydrogenase, and EC, very-long-chain acyl-CoA dehydrogenase.
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The enzyme appears in viruses and cellular organisms
ACAD 9, AcdB, acyl-CoA dehydrogenase 9, BACH, CTE-II, LCAD, long chain acyl coenzyme A dehydrogenase, long chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, long-chain acyl-CoA hydrolase, more
a long-chain acyl-CoA + electron-transfer flavoprotein = a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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