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EC 1.3.8.5 Details
EC number
1.3.8.5
Accepted name
short-chain 2-methylacyl-CoA dehydrogenase
Reaction
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+
Other name(s)
ACADSB (gene name),
2-methylacyl-CoA dehydrogenase,
branched-chain acyl-CoA dehydrogenase (ambiguous),
2-methyl branched chain acyl-CoA dehydrogenase,
2-methylbutanoyl-CoA:(acceptor) oxidoreductase,
2-methyl-branched-chain-acyl-CoA:electron-transfer flavoprotein 2-oxidoreductase,
2-methyl-branched-chain-enoyl-CoA reductase
Systematic name
short-chain 2-methylacyl-CoA:electron-transfer flavoprotein 2-oxidoreductase
Comment
A flavoprotein (FAD). The mammalian enzyme catalyses an oxidative reaction as a step in the mitochondrial β-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation. The enzyme from the parasitic helminth Ascaris suum catalyses a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA.
History
created 1992 as EC 1.3.1.52, transferred 2012 to EC 1.3.8.5 (EC 1.3.99.12, created 1986, incorporated 2020), modified 2020
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