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(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
(5Z,8Z,11Z,14Z,17Z) -5,8,11,14,17-icosapentaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
2,6-dimethylheptanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
4,8,12-trimethyltridecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
4-cis,7-cis-decadienoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis,7cis-decatrienoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis-decadienoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-decynoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
trans-2-ene-4-decynoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-oxaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
-
poor substrate, oxidized at about 10% of the rate of octanoyl-CoA
-
?
4-thiaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
-
oxidized 1.5fold faster than octanoyl-CoA
-
?
5-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,5-cis-decadienoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
6-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,6-cis-decadienoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
acyl-CoA + electron transfer flavoprotein
2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
all-cis-4,7,10,13-hexadecatetraenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-all-cis-4,7,10,13-hexadecapentaenoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
arachidonoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
arachidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
beta-(2-furyl)propionyl-CoA + electron transfer flavoprotein + 2,6-dichloroindophenol
trans-beta-(2-furyl)acryloyl-CoA + reduced acceptor
beta-(2-furyl)propionyl-CoA + O2
trans-beta-(2-furyl)acryloyl-CoA + H2O2
-
slow oxidase activity
-
?
beta-(2-furyl)propionyl-CoA + pyocyanine
trans-beta-(2-furyl)acryloyl-CoA + reduced pyocanine
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
butanoyl-CoA + electron-transfer flavoprotein
crotonoyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
r
crotonyl-CoA + H2O
L-3-hydroxy-butyryl-CoA
-
enoyl-CoA hydratase activity
-
?
decanoyl-CoA + 2,6-dichlorophenolindophenol
2-decenoyl-CoA + reduced 2,6-dichorophenolindophenol
-
-
-
-
r
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
decanoyl-CoA + electron transfer flavoprotein
(2E)-2-decenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
-
?
decanoyl-CoA + electron transfer flavoprotein
decenoyl-CoA + reduced electron transfer flavoprotein
decanoyl-CoA + ferricenium hexafluorophosphate
2-decenoyl-CoA + ferrocenium hexafluorophosphate
-
-
-
-
r
decanoyl-CoA + ferrocenium hexafluorophosphate
trans-dec-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
-
-
-
-
r
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
docosanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
dodecanoyl-CoA + electron transfer flavoprotein
dodecenoyl-CoA + reduced electron transfer flavoprotein
dodecanoyl-CoA + electron-transfer flavoprotein
+ trans-dodec-2-enoyl-CoA reduced electron-transfer flavoprotein
-
-
-
-
r
dodecanoyl-CoA + tetrazolium salt
trans-dodec-2-enoyl-CoA + reduced tetrazolium salt
-
-
-
-
r
elaidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
furylpropionyl-CoA + ferricenium hexafluorophosphate
furylacryloyl-CoA + ferrocenium hexafluorophosphate
heptadecan-2-onyl-dethio-CoA + phenazine methosulfate + 2,6-dichloroindophenol
?
heptadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
hexadecanoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-hexadecenoyl-CoA + reduced acceptor
hexanoyl-CoA + 2,6-dichloroindophenol
2-hexenoyl-CoA + reduced 2,6-dichloroindophenol
-
-
-
-
?
hexanoyl-CoA + 2,6-dichlorophenolindophenol
trans-hex-2-enoyl-CoA + reduced 2,6-dichlorophenolindophenol
-
-
-
-
r
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
hexanoyl-CoA + electron transfer flavoprotein
(2E)-2-hexenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
-
?
hexanoyl-CoA + ferricenium
trans-hex-2-enoyl-CoA + ferrocenium
-
-
-
-
r
hexanoyl-CoA + ferricenium hexafluorophosphate
trans-hex-2-enoyl-CoA + ferrocenium hexafluorophosphate
-
-
-
-
r
hexanoyl-CoA + ferrocenium hexafluorophosphate
trans-hex-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
-
-
-
-
r
hexanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-hexenoyl-CoA + reduced acceptor
-
-
-
?
hexanoyl-CoA + tetrazolium salt
trans-hex-2-enoyl-CoA + reduced tetrazolium salt
-
-
-
-
r
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
indolepropionyl-CoA + O2
indoleacryloyl-CoA + H2O2
lauroyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
lauroyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-dodecenoyl-CoA + reduced acceptor
-
-
-
?
linoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
myristoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
myristoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
n-octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-tetradecenoyl-CoA + reduced acceptor
nonanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
octadecanoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
octanoyl 3'-dephospho-CoA + 2,6-dichloroindophenol
?
-
-
-
-
?
octanoyl pantetheine + 2,6-dichloroindophenol
?
-
-
-
-
?
octanoyl-1,N6-etheno-CoA + 2,6-dichloroindophenol
?
-
-
-
-
?
octanoyl-CoA + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced 2,6-dichloroindophenol
-
optimal substrate for wild type enzyme
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
octanoyl-CoA + ferricenium
2-octenoyl-CoA + reduced acceptor
octanoyl-CoA + ferricenium hexafluorophosphate
2-octenoyl-CoA + ferrocenium hexafluorophosphate
-
medium chain acyl-CoA dehydrogenase from kidney
-
?
octanoyl-CoA + ferriocenium hexfluorophosphate
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + meldola's blue
trans-oct-2-enoyl-CoA + reduced meldola's blue
-
-
-
-
r
octanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
octanoyl-CoA + phenazine ethosulfate
trans-oct-2-enoyl-CoA + reduced phenazine ethosulfate
-
-
-
-
r
octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + recombinant beta-Y16L electron transferring flavoprotein
trans-oct-2-enoyl-CoA + reduced recombinant beta-Y16L electron transferring flavoprotein
-
-
-
-
r
octanoyl-CoA + recombinant electron transferring flavoprotein
trans-oct-2-enoyl-CoA + reduced recombinant electron transferring flavoprotein
-
-
-
-
r
oleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
palmitoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
palmitoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
pentadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
phenylpropionyl-CoA + acceptor
? + reduced acceptor
phenylpropionyl-CoA + ferricenium hexafluorophosphate
? + reduced ferricenium hexafluorophosphate
-
-
-
-
?
stearoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
tetradecanoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
tetradecanoyl-CoA + electron transfer flavoprotein
tetradecenoyl-CoA + reduced electron transfer flavoprotein
tetradecanoyl-CoA + tetrazolium salt
tetradecenoyl-CoA + reduced tetrazolium salt
-
-
-
-
r
tetradecenoyl-CoA + reduced electron transfer flavoprotein
tetradecanoyl-CoA + electron transfer flavoprotein
-
-
-
-
r
undecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
-
-
-
-
?
[4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
additional information
?
-
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
2-p-iodophenyl-3-p-nitrophenyl-5-phenyl-2H-tetrazolium chloride as final electron acceptor
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
-
-
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
chain-length specificity depending on electron acceptor: with phenazine methosulfate hexanoyl-CoA, with electron transfer flavoprotein, octanoyl-CoA
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
specific for chain lengths C6-C8
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
-
-
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
-
-
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
specific for chain lengths C4-C13
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
specific for chain lengths C6-C12
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
enzyme-substrate interactions
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate or electron transfer flavoprotein
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
enzyme-substrate interactions
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
intermediary electron acceptor: 2,6-dichloroindophenol
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate or electron transfer flavoprotein
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate or electron transfer flavoprotein
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate or electron transfer flavoprotein
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
electron acceptor: phenazine methosulfate or electron transfer flavoprotein
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
-
final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue
-
?
acyl-CoA + electron transfer flavoprotein
2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
-
first step in beta-oxidation of fatty acids
-
?
acyl-CoA + electron transfer flavoprotein
2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
-
first step in beta-oxidation of fatty acids
-
?
beta-(2-furyl)propionyl-CoA + electron transfer flavoprotein + 2,6-dichloroindophenol
trans-beta-(2-furyl)acryloyl-CoA + reduced acceptor
-
-
-
?
beta-(2-furyl)propionyl-CoA + electron transfer flavoprotein + 2,6-dichloroindophenol
trans-beta-(2-furyl)acryloyl-CoA + reduced acceptor
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
-
-
r
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
reduction potential
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
-
potentiometric measurements
-
?
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
-
-
-
?
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein
-
?
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
-
-
-
?
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
-
72% of activity with hexanoyl-CoA
-
?
decanoyl-CoA + electron transfer flavoprotein
decenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
?
decanoyl-CoA + electron transfer flavoprotein
decenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
?
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
-
-
-
-
?
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
-
electron acceptor: Meldola's Blue and iodonitrotetrazoliumchloride, general and long-chain acyl-CoA dehydrogenase
-
?
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
-
-
-
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
-
-
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
-
-
-
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
-
-
-
?
dodecanoyl-CoA + electron transfer flavoprotein
dodecenoyl-CoA + reduced electron transfer flavoprotein
preferred substrate
-
-
?
dodecanoyl-CoA + electron transfer flavoprotein
dodecenoyl-CoA + reduced electron transfer flavoprotein
preferred substrate
-
-
?
furylpropionyl-CoA + ferricenium hexafluorophosphate
furylacryloyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
furylpropionyl-CoA + ferricenium hexafluorophosphate
furylacryloyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
heptadecan-2-onyl-dethio-CoA + phenazine methosulfate + 2,6-dichloroindophenol
?
-
-
-
-
?
heptadecan-2-onyl-dethio-CoA + phenazine methosulfate + 2,6-dichloroindophenol
?
-
58% of activity with hexadecanoyl-CoA
-
-
?
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
-
-
-
?
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein, very low activity
-
?
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
-
55% of activity with hexanoyl-CoA
-
-
?
hexadecanoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-hexadecenoyl-CoA + reduced acceptor
-
-
-
-
?
hexadecanoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-hexadecenoyl-CoA + reduced acceptor
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
-
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
-
-
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein, best substrate with phenazine methosulfate
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
100% activity
-
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
-
-
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
-
best substrate
-
-
?
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
-
chromogenic substrate showing a strong absorption band in the near visible region
-
?
indolepropionyl-CoA + O2
indoleacryloyl-CoA + H2O2
-
very low activity
-
?
indolepropionyl-CoA + O2
indoleacryloyl-CoA + H2O2
-
very low activity
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
best substrate with electron transferring flavoprotein
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
fibroblast medium-chain acyl-CoA dehydrogenase is specific towards C6-C8 acyl-CoA esters
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
best substrate for medium-chain acyl-CoA dehydrogenase
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
no activity with tetradecanoyl-CoA and hexadecanoyl-CoA
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
no activity with tetradecanoyl-CoA and hexadecanoyl-CoA
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
82% of activity with hexanoyl-CoA
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
-
phenazine methosulfate substituted by electron transfer flavoprotein
-
?
n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-tetradecenoyl-CoA + reduced acceptor
-
best substrate for long-chain acyl-CoA dehydrogenase
-
?
n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-tetradecenoyl-CoA + reduced acceptor
-
best substrate for long-chain acyl-CoA dehydrogenase
-
?
octadecanoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
-
-
-
-
?
octadecanoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein, extremely low activity
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
-
-
-
-
?
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
-
-
-
-
?
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
-
-
-
-
?
octanoyl-CoA + ferricenium
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
octanoyl-CoA + ferricenium
2-octenoyl-CoA + reduced acceptor
-
-
-
-
?
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein
-
?
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
-
-
-
-
?
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
-
68% of activity with hexanoyl-CoA
-
?
phenylpropionyl-CoA + acceptor
? + reduced acceptor
-
-
-
-
?
phenylpropionyl-CoA + acceptor
? + reduced acceptor
-
110% activity
-
-
?
tetradecanoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
-
-
-
?
tetradecanoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
-
acceptors: phenazine methosulfate or electron transferring flavoprotein, low activity
-
?
tetradecanoyl-CoA + electron transfer flavoprotein
tetradecenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
?
tetradecanoyl-CoA + electron transfer flavoprotein
tetradecenoyl-CoA + reduced electron transfer flavoprotein
-
-
-
?
[4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
[4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
-
-
-
?
additional information
?
-
-
involved in the formation of unsaturated fatty acid
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
enzyme shows a preference towards esters of even chain length and very low activity with C3C9 acyl-CoA esters as substrates
-
-
?
additional information
?
-
-
a Y42H mutation is frequently found in babies identified by newborn screening with MS/MS. Y42H is a temperature sensitive mutation, which is mild at low temperatures, but may have deleterious effects at increased temperatures
-
-
?
additional information
?
-
-
key enzyme for the beta-oxidation of fatty acids
-
-
?
additional information
?
-
-
acts on a wide range of chain lengths (C16-C4)
-
-
?
additional information
?
-
-
beta-oxidation enzymes encoded by the pim gene cluster including acyl CoA dehydrogenase are active with medium-chain-length dicarboxylic acids
-
-
?
additional information
?
-
-
substrate/product binding results in ligand polarization and positive flavin potential shifts, which activate the enzyme for electron transfer
-
-
?
additional information
?
-
-
acts on a wide range of chain lengths (C16-C4)
-
-
?
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A1010C
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency
A151T
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
A293E
less than 5% residual octanoyl-CoA oxidation activity
A52V
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
A533C
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency
D221N
less than 5% residual octanoyl-CoA oxidation activity
D266G
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
D320Y
less than 5% residual octanoyl-CoA oxidation activity
D79X
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
delT125, E126
less than 5% residual octanoyl-CoA oxidation activity
E376G
-
the rate of dehydrogenation is lowered by approximately 5 orders of magnitude
E376Q/E99G
-
the rate of dehydrogenation is lowered by 4-5 orders of magnitude
F194S
less than 5% residual octanoyl-CoA oxidation activity
G127A
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency, not clearly associated with a clinical phenotype
G170R
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
G242R
less than 5% residual octanoyl-CoA oxidation activity
G285R
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
G799A
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency
I208T
about 5% residual octanoyl-CoA oxidation activity
K153T
less than 5% residual octanoyl-CoA oxidation activity
K276X
less than 5% residual octanoyl-CoA oxidation activity
L59F
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
L73DELTA
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
M303V
less than 5% residual octanoyl-CoA oxidation activity
N169D
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
N354K
about 8% residual octanoyl-CoA oxidation activity
N396Y
-
involved in MCAD deficiency with a MCAD activity of 11.2% compared to the wild type enzyme, in combination with the deletion mutation DELTA449-CTGA-452
P128X
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
Q20R
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
R123K
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
R206C
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
R256S
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
R334K
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
R413S
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
R6H
about 45% residual octanoyl-CoA oxidation activity
T1229G
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency
T168A
-
thermostability is markedly decreased, 80% lowered activity in ferricinum assay
T199C
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency, not clearly associated with a clinical phenotype
T255E
-
same activity with octanoyl-CoA as wild-type, activity/chain length profile is, however, narrower
T255E/E376G
-
chimeric medium-long chain acyl-CoA dehydrogenase, has 20% of the activity of medium-chain acyl-CoA dehydrogenase and 25% that of long-chain acyl-CoA dehydrogenase activity with its best substrates octanoyl-CoA and dodecanoyl-CoA respectively, activity maximum is shifted to C12 and C14-CoA, enzyme shows an enhanced rate of reoxidation with oxygen
T255E/E376T
-
shifts the chain length activity profile to higher values, drastic reduction of maximal velocity
T92T
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
T96I
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
V247A
less than 5% residual octanoyl-CoA oxidation activity
V362V
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
Y158H
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
Y312S
about 8% residual octanoyl-CoA oxidation activity
Y394X
less than 5% residual octanoyl-CoA oxidation activity
Y67H
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
K304E
-
maximal velocity of the mutant protein is only one third of the wild-type value. 16% higher activity with the natural electron acceptor, electron transferring flavoprotein, than the wild-type enzyme. Decreased stability at temperatures above 42°C compared to wild-type enzyme
R256K
-
3.6fold increase in Km-value for octanoyl-CoA, 45fold decrease in turnovernumber with octanoyl-CoA compared to wild-type enzyme
Y375A
-
very low acyl-CoA dehydrogenase activity
Y375F
-
very low acyl-CoA dehydrogenase activity
Y375K
-
very low acyl-CoA dehydrogenase activity, mutant exhibits acyl-CoA oxidase activity
Y42H
-
mutant enzyme has approximately the same maximal velocity as the wild-type enzyme, the KM-value for octanoyl-CoA is 1.6fold higher than the wild-type value. 7% higher activity with the natural electron acceptor, electron transferring flavoprotein, than the wild-type enzyme. Decreased stability at temperatures above 42°C compared to wild-type enzyme
E276Q
-
no detectable activity in ferricenium assay
E376P
-
no detectable activity in ferricenium assay
A31P
-
involved in medium chain acyl-CoA dehydrogenase deficiency
A31P
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
A985G
-
involved in MCAD deficiency
A985G
-
mutant is involved in medium chain acyl-CoA dehydrogenase deficiency
A985G
-
in the Brazilian population, about 0.41% of individuals are heterozygous for the A985G mutation. The mutant homozygous genotype was not found
A985G
-
genotype, the naturally occuring mutation is involved in medium-chain acyl-CoA dehydrogenase deficiency, phenotype, overview
E18K
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
E18K
about 47% residual octanoyl-CoA oxidation activity
E376Q
-
mutation slows down the octanoyl-CoA-dependent reductive half-reaction of the enzyme by about 5 orders of magnitude due to impairment in the proton transfer step, also impairs the association and dissociation rates for the binding of the reaction product octenoyl-CoA. Km-value for octanoyl-CoA is 1.6fold reduced, turnover number for octenoyl-CoA is 7083fold reduced compared to wild-type enzyme
E376Q
-
the rate of dehydrogenation is lowered by 4-5 orders of magnitude
K304E
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
K304E
less than 5% residual octanoyl-CoA oxidation activity
K329E
-
reported to be responsible for medium-chain CoA dehydrogenase deficiency
K329E
mutation identified in a newborn. Mutatio lowers the temperature threshold at which loss-of-function occurs
Y42H
-
the mutation is involved in medium chain acyl-CoA dehydrogenase deficiency
Y42H
about 22% residual octanoyl-CoA oxidation activity
additional information
-
lipB insertion mutant, zone of growth inhibition around mutant is only ca. 62% of the wild-type inhibition zone indicating a reduced friulimicin production or a modified, less biologically active friulimicin production
additional information
-
AF-toxin I is 55.5% and 97.9% lower in mutant strains 24.1 and 24.1.8, respectively, than in the wild type, AF-toxin II production decreases to almost 70% in strain 24.1 and up to 90% in strain 24.1.8
additional information
-
among 11 Japanese patients with medium-chain acyl-CoA dehydrogenase deficiency, mutation c.449-452delCTGA accounts for 45%. Seven of 10 independent patients carried at least one copy of the mutation. Phenotypes of homozygous patients with the c.449-452delCTGA mutation varied from asymtomatic to life-threatening metabolic decompensations
additional information
-
mutant strain deleted in the pim gene cluster, grows at about half the rate of the wild-type parent when benzoate or pimelate is supplied as the sole carbon source, grows five times more slowly than the wild-type on the C14 dicarboxylic acid tetradecanedioate, but is unimpaired in growth on the C8-fatty acid caprylate
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