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Information on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.7

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IUBMB Comments

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds . The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds . cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.

The enzyme appears in viruses and cellular organisms

Synonyms
medium-chain acyl-coa dehydrogenase, acadm, medium chain acyl-coa dehydrogenase, acyl coa dehydrogenase, medium-chain acyl-coenzyme a dehydrogenase, acyl coenzyme a dehydrogenase, mcadh, medium-chain acyl coa dehydrogenase, acyl dehydrogenase, pmcad, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
2-methyl-branched fatty acid beta-oxidation, adipate degradation, fatty acid salvage, oleate beta-oxidation