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EC 4.1.1.77 Details
EC number
4.1.1.77
Accepted name
2-oxo-3-hexenedioate decarboxylase
Reaction
(3E)-2-oxohex-3-enedioate = 2-oxopent-4-enoate + CO2
Other name(s)
4-oxalocrotonate carboxy-lyase (misleading),
4-oxalocrotonate decarboxylase (misleading),
cnbF (gene name),
praD (gene name),
amnE (gene name),
nbaG (gene name),
xylI (gene name)
Systematic name
(3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming)
CAS registry number
37325-55-6
Comment
Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enzyme has been reported to accept multiple tautomeric forms [1-4]. However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, 2-hydroxymuconate tautomerase, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate [4].
History
created 1999, modified 2011, modified 2012
EC Tree
4.1.1.10 created 1961, deleted 1972
4.1.1.13 created 1961, deleted 1972
4.1.1.26 created 1961, deleted 1972
4.1.1.27 created 1961, deleted 1972