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Information on EC 5.3.2.6 - 2-hydroxymuconate tautomerase

for references in articles please use BRENDA:EC5.3.2.6
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IUBMB Comments
Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex-3-enedioate by the enzyme . Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme [1,2] but later shown to be produced non-enzymically .
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Word Map
  • 5.3.2.6
  • germline
  • brca1/2
  • founder
  • predisposition
  • counsel
  • estrogen
  • high-risk
  • ashkenazi
  • jewish
  • checkpoint
  • prophylactic
  • heterozygosity
  • early-onset
  • population-based
  • predispose
  • brca1-associated
  • unselected
  • mastectomy
  • probands
  • oophorectomy
  • parp
  • ductal
  • woman
  • serous
  • triple-negative
  • unclassified
  • centrosome
  • risk-reducing
  • non-carriers
  • salpingo-oophorectomy
  • platinum-based
  • ligation-dependent
  • fallopian
  • basal-like
  • heteroduplex
  • dna-damaging
  • pt
  • first-degree
  • hypermethylation
  • end-joining
  • dhplc
  • homology-directed
  • mutation-positive
  • second-degree
  • methylation-specific
  • manchester
  • olaparib
  • mutation-negative
  • mammography
  • fancd2
The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
4-oxalocrotonate tautomerase, afdmpi, hpdmpi, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
show the reaction diagram
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