6.3.4.16: carbamoyl-phosphate synthase (ammonia)

This is an abbreviated version!
For detailed information about carbamoyl-phosphate synthase (ammonia), go to the full flat file.

Reaction

2 ATP +

Synonyms

arginine-specific CPS, CarB, carbamate kinase-like carbamoyl phosphate synthetase, carbamate kinase-like carbamoyl-phosphate synthetase, carbamoyl phosphate synthase-1, carbamoyl phosphate synthetase, carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase I, carbamoyl phosphate synthetase-1, carbamoyl-phosphate synthetase, carbamoyl-phosphate synthetase 1, Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthase (ammonia), Carbamoylphosphate synthetase, Carbamoylphosphate synthetase (ammonia), Carbamoylphosphate synthetase I, carbamoylphosphate synthetase-I, Carbamyl phosphate synthase I, carbamyl phosphate synthetase I, carbamyl-phosphate synthetase I, Carbamylphosphate synthetase, carbamylphosphate synthetase 1, Carbamylphosphate synthetase I, carbmoylphosphate synthetase, Carbon-dioxide-ammonia ligase, Carbonate kinase (phosphorylating), CK-like CPS, CPS, CPS 1, CPS I, CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent), CPS-1, CPS-I, CPS1, CPSase, CPSase I, CPSI, EC 2.7.2.5, mitochondrial carbamoylphosphate synthetase I, MS-s, Msm_0361, p165, urea-specific CPS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.16 carbamoyl-phosphate synthase (ammonia)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
42	Activating Compound
160	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1036	Disease/ Diagnostics
3	Expression
12	General Information
8	General Stability
39	Inhibitors
3	kcat/KM [mM/s]
4	Ki Value [mM]
64	KM Value [mM]
36	Localization
22	Metals/Ions
29	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
224	Organism
8	Pathway
12	PDB ID
12	pH Optimum
4	pH Range
3	pI Value
5	Posttranslational Modification
48	Protein Variants
17	Purification (Commentary)
10	Reaction
1	Reaction Type
84	Reference
77	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
90	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
11	Temperature Stability [°C]
8	Turnover Number [1/s]

General Stability

print visible entries

print all entries

General Stability on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to General Stability Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

acetylglutamate ATP accelerates the oxidative inactivation by mixtures of Fe3+, ascorbate, and O2

Rattus norvegicus

-

1472

elastase inactivates. Addition of ATP, Mg2+, K+ and N-acetyl-L-glutamate protects entirely

Mesocricetus auratus

-

1451

elastase inactivates. Addition of ATP, Mg2+, K+ and N-acetyl-L-glutamate protects entirely. Acetylglutamate alone speeds inactivation

Rattus norvegicus

-

1451

glycerol and DTT stabilize during purification

Rattus norvegicus

-

1456

inactivated by the Fe3+-oxygen-ascorbate model system for mixed-function oxidation. The susceptibility is markedly increased by acetylglutamate, when ATP is absent. ATP, and even more a mixture of ATP and bicarbonate protect from inactivation

Rattus norvegicus

-

1458

no inactivation by elastase

Frog

-

1451

stabilty under pressure, progressive inactivation down to 50% of initial activity at 200 MPa, this residual activity is constant at 200 MPa for at least 50 min

Pyrococcus abyssi

-

722163

trypsin, chymotrypsin, and papain also hydrolyze the oxidized enzyme considerybly faster than the native enzyme

Rattus norvegicus

-

1458