5.2.1.5: linoleate isomerase

This is an abbreviated version!
For detailed information about linoleate isomerase, go to the full flat file.

Reaction

Synonyms

C12 isomerase, FG02668.1, Isomerase, linoleate, IV39_GL000089, LA isomerase, LA-I, LAI, LAI12, Linoleate DELTA12-cis,DELTA11-trans isomerase, linoleic acid DELTA12-cis,DELTA11-trans-isomerase, Linoleic acid isomerase, PAI

ECTree

     5 Isomerases

         5.2 cis-trans-Isomerases

             5.2.1 cis-trans Isomerases (only sub-subclass identified to date)

                5.2.1.5 linoleate isomerase

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Results	in table
13	Activating Compound
14	AA Sequence
12	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Cofactor
2	Expression
4	General Information
2	General Stability
48	Inhibitors
10	KM Value [mM]
6	Localization
1	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
44	Organism
1	Pathway
3	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
5	Purification (Commentary)
4	Reaction
2	Reaction Type
42	Reference
4	Source Tissue
8	Specific Activity [micromol/min/mg]
1	Storage Stability
53	Substrates and Products (Substrate)
5	Subunits
51	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 5.2.1.5 - linoleate isomerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

5 entries

11-cis,14-cis-eicosadienoic acid

?

Clostridium sporogenes

-

-

679570

-

-

?

2,5-Octadecadienoic acid

3,5-Octadecadienoic acid

Butyrivibrio fibrisolvens

-

-

2494

-

2494

?

6-cis,9-cis,12-cis,15-cis-octadecatetraenoic acid

?

Clostridium sporogenes

-

i.e. stearidonic acid

679570

-

-

?

6-cis,9-cis,12-cis-octadecatrienoic acid

?

Clostridium sporogenes

-

i.e. alpha-linolenic acid

679570

-

-

?

9-cis,11-trans-linoleic acid

9-trans,11-trans-linoleic acid

3 entries

9-cis,12-cis,15-cis-octadecatrienoic acid

?

Clostridium sporogenes

-

i.e. gamma-linolenic acid

679570

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

20 entries

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid + 9-trans,11-trans-linoleic acid

2 entries

9-cis,12-cis-linoleic acid

9-trans,11-trans-linoleic acid

3 entries

9-cis,12-cis-Octadecadienoate

9-cis,11-trans-Octadecadienoate

4 entries

9-cis,12-cis-Octadecadienoate

?

Butyrivibrio fibrisolvens

-

initial reaction of the biohydrogenation pathway

2495

-

-

?

cis-9,cis-12,cis-15-octadecatrienoic acid

cis-9,trans-11,cis-15-octadecatrienoic acid

Butyrivibrio fibrisolvens

-

-

2496

-

2496

?

linoleic acid

(9E,11E)-octadeca-9,11-dienoic acid

Lactobacillus acidophilus

Q307I4

-

691788

-

-

?

linoleic acid

(9Z,11E)-octadeca-9,11-dienoic acid

2 entries

linoleic acid

conjugated linoleic acid

2 entries

additional information

?

-

2 entries

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Butyrivibrio hungatei

-

-

679938

i.e. rumenic acid

-

?

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Butyrivibrio hungatei A38

-

-

679938

i.e. rumenic acid

-

?

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Pseudobutyrivibrio ruminis

-

-

679938

i.e. rumenic acid

-

?

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Pseudobutyrivibrio xylanivorans

-

-

679938

i.e. rumenic acid

-

?

(9Z,12Z)-octadeca-9,12-dienoic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Pseudobutyrivibrio xylanivorans JW11

-

-

679938

i.e. rumenic acid

-

?

9-cis,11-trans-linoleic acid

9-trans,11-trans-linoleic acid

Clostridium sporogenes

-

formation only under aerobic conditions

679570

-

-

?

9-cis,11-trans-linoleic acid

9-trans,11-trans-linoleic acid

Lactiplantibacillus plantarum

Q88ZZ7

-

748054

-

-

?

9-cis,11-trans-linoleic acid

9-trans,11-trans-linoleic acid

Lactiplantibacillus plantarum ZS20580

Q88ZZ7

-

748054

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Butyrivibrio hungatei

-

-

679938

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Butyrivibrio hungatei A38

-

-

679938

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Clostridium sporogenes

-

higher activity under aerobic than under anaerobic conditions

679570

conjugated linoleic acid isomer

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactiplantibacillus plantarum

F0V4E8

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactiplantibacillus plantarum ATCC 8014

F0V4E8

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactobacillus acidophilus

-

-

681731, 713871

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactobacillus acidophilus ATCC 55739

-

-

713871

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactobacillus acidophilus L1

-

-

681731

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactobacillus delbrueckii subsp. bulgaricus

-

-

714488

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Lactobacillus delbrueckii subsp. bulgaricus 1.1480

-

-

714488

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Latilactobacillus curvatus

F0V5Y1

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Latilactobacillus curvatus LMG 13553

F0V5Y1

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Latilactobacillus sakei

F0V4F4

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Latilactobacillus sakei LMG 13558

F0V4F4

-

715320

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Limosilactobacillus reuteri

-

-

681731

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Limosilactobacillus reuteri

-

the enzyme shows high specificity for the production of the cis-9, trans-11 conjugated linoleic acid isomer

715314

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Limosilactobacillus reuteri ATCC 55739

-

the enzyme shows high specificity for the production of the cis-9, trans-11 conjugated linoleic acid isomer

715314

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Pseudobutyrivibrio ruminis

-

-

679938

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Pseudobutyrivibrio xylanivorans

-

-

679938

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid

Pseudobutyrivibrio xylanivorans JW11

-

-

679938

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid + 9-trans,11-trans-linoleic acid

Lactiplantibacillus plantarum

-

-

714537

-

-

?

9-cis,12-cis-linoleic acid

9-cis,11-trans-linoleic acid + 9-trans,11-trans-linoleic acid

Lactiplantibacillus plantarum AKU1009a

-

-

714537

-

-

?

9-cis,12-cis-linoleic acid

9-trans,11-trans-linoleic acid

Lactobacillus acidophilus

-

-

681731

-

-

?

9-cis,12-cis-linoleic acid

9-trans,11-trans-linoleic acid

Lactobacillus acidophilus L1

-

-

681731

-

-

?

9-cis,12-cis-linoleic acid

9-trans,11-trans-linoleic acid

Limosilactobacillus reuteri

-

-

681731

-

-

?

9-cis,12-cis-Octadecadienoate

9-cis,11-trans-Octadecadienoate

Bacteria

-

-

702946

-

-

?

9-cis,12-cis-Octadecadienoate

9-cis,11-trans-Octadecadienoate

Butyrivibrio fibrisolvens

-

-

2495

-

2495

?

9-cis,12-cis-Octadecadienoate

9-cis,11-trans-Octadecadienoate

Butyrivibrio fibrisolvens

-

r

2496

-

2496

?

9-cis,12-cis-Octadecadienoate

9-cis,11-trans-Octadecadienoate

Butyrivibrio fibrisolvens

-

9,12-octadienoic acid

2494

-

2494

?

linoleic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Butyrivibrio fibrisolvens

-

-

691788

-

-

?

linoleic acid

(9Z,11E)-octadeca-9,11-dienoic acid

Lactobacillus acidophilus

Q307I4

-

691788

-

-

?

linoleic acid

conjugated linoleic acid

Lactobacillus acidophilus

-

-

713871

-

-

?

linoleic acid

conjugated linoleic acid

Lactobacillus acidophilus ATCC 55739

-

-

713871

-

-

?

additional information

?

-

Clostridium sporogenes

-

substrate specificity, overview, the enzyme is specific for substrates containing cis double bonds at the c9 and c12 positions of C18 polyunsaturated fatty acids, a free carboxyl group is absolutely necessary for isomerization

679570

-

-

?

additional information

?

-

Lactobacillus acidophilus

Q307I4

enzyme shows oleate hydratase activity, reaction of EC 4.2.1.53, but does not display linoleate isomerase activity

747692

-

-

?