5.2.1.5: linoleate isomerase

This is an abbreviated version!
For detailed information about linoleate isomerase, go to the full flat file.

Word Map on EC 5.2.1.5

Reaction

9-cis,12-cis-octadecadienoate
=
9-cis,11-trans-octadecadienoate

Synonyms

Isomerase, linoleate, Linoleic acid isomerase, Linoleate DELTA12-cis,DELTA11-trans isomerase, PAI, LA-I, linoleic acid DELTA12-cis,DELTA11-trans-isomerase, LA isomerase, LAI, C12 isomerase, IV39_GL000089, LAI12, FG02668.1

ECTree

     5 Isomerases
         5.2 cis-trans-Isomerases
             5.2.1 cis-trans Isomerases (only sub-subclass identified to date)
                5.2.1.5 linoleate isomerase

Inhibitors

Inhibitors on EC 5.2.1.5 - linoleate isomerase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
reversible, noncompetitive
10,13-Octadecadienoic acid
-
inhibits isomerization of 9,12-octadienoic acid
11,14-Octadecadienoic acid
-
inhibits isomerization of 9,12-octadienoic acid
12,15-Octadecadienoic acid
-
inhibits isomerization of 9,12-octadienoic acid
4,7-Octadecadienoic acid
-
inhibits isomerization of 2,5-octadecadienoic acid and 9,12-octadecadienic acid
5,8-Octadecadienoic acid
-
inhibits isomerization of 2,5-octadecadienoic acid and 9,12-octadecadienic acid
7,10-Octadecadienoic acid
-
inhibits isomerization of 9,12-octadienoic acid
8,11-Octadecadienoic acid
-
inhibits isomerization of 9,12-octadienoic acid
9-cis,12-cis-linoleic acid methyl ester
-
i.e. methyl linoleate, 31% inhibition at 0.02 mM
9-cis,12-cis-octadecadien-1-ol
-
i.e. linoleyl alcohol, 19% inhibition at 0.02 mM
cis,cis,3,6-Octadecadienoic acid
-
inhibits isomerization of 2,5-octadecadienoic acid and 9,12-octadecadienic acid
cis-11,cis-14-Eicosadienic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
cis-6,cis-9-Octadecadienic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
cis-8,cis11-Heptadecadienic acid
-
-
cis-9,trans-12-Octadecadienoic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
cis-9-Octadecen-12-ynoic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
EGTA
-
93% residual activity at 3 mM
gamma-linolenic acid
-
substrate inhibition at concentrations above 0.015 mM
iodoacetamide
-
-
Linoleamide
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
linoleic acid
linolelaidic acid
-
81% inhibition at 0.02 mM
linolenic acid
-
substrate inhibition at concentrations above 0.04 mM
Linoleyl alcohol
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
linoleyl amine
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
Linoleyl hydrazide
-
-
Linoleyl hydroxamate
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
Linoleyl methyl ether
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
Linoleyl methyl ketone
-
weak inhibition
Linoleyl oxime
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
methyl linoleate
-
weak inhibition
methyl oleate
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
o-phenanthroline
-
10% residual activity at 3 mM
oleic acid
-
75% inhibition at 0.02 mM
oleyl alcohol
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
oleyl amine
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
p-hydroxymercuribenzoate
-
-
palmitoleic acid
-
72% inhibition at 0.02 mM
stearidonic acid
-
substrate inhibition at concentrations above 0.120 mM
trans-11-Octadecen-9-ynoic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
trans-3,cis-5-Octadecadienoic acid
-
inhibits isomerization of 2,5-octadecadienoic acid
trans-9,cis-12-Octadecadienoic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
trans-9,trans-12-Octadecadienoic acid
-
inhibits isomerization of 9-cis,12-cis-octadecadienoate
additional information
-
no effects by DTT, ATP, ADP, NAD+, NADH, NADPH or CoA
-