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3.5.4.25: GTP cyclohydrolase II

This is an abbreviated version!
For detailed information about GTP cyclohydrolase II, go to the full flat file.

Word Map on EC 3.5.4.25

Reaction

GTP
+ 4 H2O =
formate
 +
2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine
 + 2 phosphate

Synonyms

3,4-dihydroxy-2-butanone 4-phosphate synthase, GCH II, GCH II/III, GCH-II, gch2, GCHII, GTP 7,8-8,9-dihydrolase (diphosphate-forming), GTP cyclohydrolase 2, GTP cyclohydrolase II, GTP cyclohydrolase-II, GTP-8-formylhydrolase, GTPCH II, GTPCH-II, guanosine triphosphate cyclohydrolase II, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, guanosine-5'-triphosphate cyclohydrolase-II, More, NbRibA, ribA, ribA2, RIBIV, ToxB

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.25 GTP cyclohydrolase II

Cloned

Cloned on EC 3.5.4.25 - GTP cyclohydrolase II

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
expression in Escherichia coli
expression of wild-type and mutant enzymes
-
gene ribA2, DNA and amino acid sequence analysis and comparison of DHBPS/GTPCH-II sequences
-
overexpression and purification of wild type and site-directed variants of GCH II
overexpression in strain 1012 by gene insertion in the sacB locus
-