3.5.4.25: GTP cyclohydrolase II

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For detailed information about GTP cyclohydrolase II, go to the full flat file.

Reaction

Synonyms

3,4-dihydroxy-2-butanone 4-phosphate synthase, GCH II, GCH II/III, GCH-II, gch2, GCHII, GTP 7,8-8,9-dihydrolase (diphosphate-forming), GTP cyclohydrolase 2, GTP cyclohydrolase II, GTP cyclohydrolase-II, GTP-8-formylhydrolase, GTPCH II, GTPCH-II, guanosine triphosphate cyclohydrolase II, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, guanosine-5'-triphosphate cyclohydrolase-II, More, NbRibA, ribA, ribA2, RIBIV, ToxB

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.25 GTP cyclohydrolase II

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Results	in table
31774	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Crystallization (Commentary)
15	General Information
12	Inhibitors
2	kcat/KM [mM/s]
1	Ki Value [mM]
39	KM Value [mM]
13	Metals/Ions
10	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
30	Organism
12	Pathway
7	PDB ID
8	pH Optimum
2	pH Range
1	pI Value
32	Protein Variants
8	Purification (Commentary)
5	Reaction
4	Reaction Type
30	Reference
3	Source Tissue
14	Specific Activity [micromol/min/mg]
2	Storage Stability
39	Substrates and Products (Substrate)
3	Subunits
39	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
35	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.5.4.25 - GTP cyclohydrolase II

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

selenomethionine-labeled crystals, 1.54 A resolution

Escherichia coli

-

674493

the enzyme is crystallized in oxidized form, the expulsion of Zn(2+) upon oxidation of catalytic cysteines reveales its ability to act in response to the redox environment. The crystal structure of Helicobacter pylori, unlike other GCHII structures, reveales that cysteines at the active site exist in oxidized state forming two disulfide bonds

Helicobacter pylori

O08315

757510

sitting drop vapor diffusion method, using 0.1 M Na HEPES pH 7.5, 15% (w/v) PEG 8000

Mycobacterium tuberculosis

P9WHF1

726585