3.5.4.25: GTP cyclohydrolase II
This is an abbreviated version!
For detailed information about GTP cyclohydrolase II, go to the full flat file.
Word Map on EC 3.5.4.25
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3.5.4.25
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riboflavin
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anti-hcv
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lumazine
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guilliermondii
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famata
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gtp-cyclohydrolase
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2,5-diamino-6-ribosylamino-43h-pyrimidinone
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flavinogenic
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6,7-dimethyl-8-ribityllumazine
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pharmacology
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synthesis
- 3.5.4.25
- riboflavin
-
anti-hcv
- lumazine
- guilliermondii
- famata
-
gtp-cyclohydrolase
-
2,5-diamino-6-ribosylamino-43h-pyrimidinone
-
flavinogenic
- 6,7-dimethyl-8-ribityllumazine
- pharmacology
- synthesis
Reaction
Synonyms
3,4-dihydroxy-2-butanone 4-phosphate synthase, GCH II, GCH II/III, GCH-II, gch2, GCHII, GTP 7,8-8,9-dihydrolase (diphosphate-forming), GTP cyclohydrolase 2, GTP cyclohydrolase II, GTP cyclohydrolase-II, GTP-8-formylhydrolase, GTPCH II, GTPCH-II, guanosine triphosphate cyclohydrolase II, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, guanosine-5'-triphosphate cyclohydrolase-II, More, NbRibA, ribA, ribA2, RIBIV, ToxB
ECTree
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Metals Ions
Metals Ions on EC 3.5.4.25 - GTP cyclohydrolase II
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Mg2+
Zn2+
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wild-type enzyme contains 0.71 mol Zn2+ per mol of subunit, while the content in the mutant enzymes is reduced to below 0.1 mol Zn2+ per mol of subunit, essential for activity, bound to the active site, required for ring opening and formate release with zinc acting as a Lewis acid, which activates the 2 water molecules involved in the sequential hydrolysis of 2 carbon-nitrogen bonds
Zn2+
content 1 molecule per monomer enzyme, enzyme requires a zinc ion which presumably activates a water molecule for excision of C-8 of GTP
Zn2+
content of 1 molecule per enzyme monomer, enzyme requires a zinc ion which presumably activates a water molecule for excision of C-8 of GTP