3.4.24.67: choriolysin H

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For detailed information about choriolysin H, go to the full flat file.

Reaction

Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr-/-7-(4-methyl)coumarylamide =

Synonyms

chorionase, embryo-specific hatching enzyme, FHCE1, FHCE2, hatching enzyme, HCE, HCE-1, HCE1, HCE2, High choriolytic enzyme, medaka hatching enzyme, MHCE, More, PHE, Teleost hatching enzyme (component), ZHE1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.67 choriolysin H

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Results	in table
8	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
3	General Information
24	Inhibitors
2	KM Value [mM]
4	Localization
12	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
20	Organism
1	PDB ID
8	pH Optimum
3	pH Range
10	Purification (Commentary)
1	Reaction
1	Reaction Type
19	Reference
31	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
67	Substrates and Products (Substrate)
5	Subunits
34	Synonyms
6	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

General Information

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General Information on EC 3.4.24.67 - choriolysin H

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Hippocampus abdominalis

-

only gene expression of high choriolytic enzyme (HCE) and not of low choriolytic enzyme (LCE),is detected. The seahorse LCE gene is pseudogenized during evolution

754301

physiological function

2 entries

physiological function

Xiphophorus maculatus

-

generally high choriolytic enzyme (HCE) and low choriolytic enzyme (LCE) cooperatively digest the egg envelope, that is, HCE swells and softens the egg envelope by its proteolytic action, and then, LCE completely digests the swollen envelope. Gene cloning analysis reveals that in Xiphophorus maculatus the LCE is pseudogenized since open reading frame is not complete. Thus, the hatching of black rockfish is performed only by HCE, that is, after the egg envelope is swelled and softened by HCE, the embryos ruptured the envelope by their movement

754300

physiological function

Rhabdoblennius nitidus

-

the egg envelope is cooperatively solubilized by high choriolytic enzyme (HCE) and low choriolytic enzyme (LCE). High choriolytic enzyme swells the intact egg envelope, and then low choriolytic enzyme solubilizes the swollen envelope. The lower expression level of LCE but also different components of the egg-envelope protein result in an inefficient hatching enzyme/egg-envelope digestion system in this species

754302