3.4.23.19: Aspergillopepsin II
This is an abbreviated version!
For detailed information about Aspergillopepsin II, go to the full flat file.
Reaction
preferential cleavage in B chain of insulin: Asn3-/-Gln, Gly13-/-Ala, Tyr26-/-Thr =
Synonyms
acid proteinase, acid proteinase A, AGP, aspergilloglutamic peptidase, Aspergillus niger var. macrosporus aspartic proteinase, Aspergillus proteinase A, EC 3.4.23.6, More, non-pepsin type acid proteinase, Proctase A, Proteinase A
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.23.19 - Aspergillopepsin II
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proteolytic modification
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the zymogen is autocatalytically activated under acidic conditions to the mature enzyme with a two-chain structure. The major pathway of activation includes initial fast cleavage at Glu12-Ala13, followed by stepwise cleavages in the N-terminal and intervening propeptide regions. The same activation profile is obtained with the recombinant zymogen lacking the N-terminal 12-aa sequence
proteolytic modification
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the enzyme is synthesized as preproform and performs autoprocessing to the mature enzyme
proteolytic modification
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the enzyme is synthesized as preproform and performs autoprocessing to the mature enzyme removing the 41-amino acid propeptide and an 11-amino acid intervening peptide
proteolytic modification
-
the enzyme is synthesized as preproform and performs autoprocessing to the mature enzyme removing the 41-amino acid propeptide and an 11-amino acid intervening peptide, overview