3.4.23.19: Aspergillopepsin II
This is an abbreviated version!
For detailed information about Aspergillopepsin II, go to the full flat file.
Reaction
preferential cleavage in B chain of insulin: Asn3-/-Gln, Gly13-/-Ala, Tyr26-/-Thr =
Synonyms
acid proteinase, acid proteinase A, AGP, aspergilloglutamic peptidase, Aspergillus niger var. macrosporus aspartic proteinase, Aspergillus proteinase A, EC 3.4.23.6, More, non-pepsin type acid proteinase, Proctase A, Proteinase A
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Reference
Reference on EC 3.4.23.19 - Aspergillopepsin II
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Tanaka, N.; Takeuchi, M.; Ichishima, E.
Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity
Biochim. Biophys. Acta
485
406-416
1977
Aspergillus niger
Chang, W.Y.; Horiuchi, S.; Takahashi, K.; Yamasaki, M.; Yamada, Y.
The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus
J. Biochem.
80
975-981
1976
Aspergillus niger
Iio, K.; Yamasaki, M.
Specificity of acid proteinase A from Aspergillus niger var. macrosporus towards B-chain of performic acid oxidized bovine insulin
Biochim. Biophys. Acta
429
912-924
1976
Aspergillus niger
Tanokura, M.; Sasaki, H.; Muramatsu, T.; Iwata, S.; Hamaya, T.; Takizawa, T.; Takahashi, K.
A new crystal form of proteinase A, a non-pepsin-type acid proteinase from Aspergillus niger var. macrosporus
J. Biochem.
114
457-458
1993
Aspergillus niger
Takahashi, K.; Kagami, N.; Huang, X.P.; Kojima, M.; Inoue, H.
Aspergillus niger acid proteinase A. Structure and function
Adv. Exp. Med. Biol.
436
275-282
1998
Aspergillus niger
Komatsu, S.; Nishii, W.; Sasaki, H.; Muramatsu, T.; Tanokura, M.
Substrate specificity of non-pepsin-type acid proteinase, Aspergillus niger proteinase A
Adv. Exp. Med. Biol.
436
345-348
1998
Aspergillus niger
Maeda, M.; Takeuchi, K.; Kojima, M.; Tanokura, M.; Kimura, K.; Amemiya, Y.; Kihara, H.; Takahashi, K.
Kinetic studies of unfolding process of aspergillopepsin II by pH-jump methods
Biochem. Biophys. Res. Commun.
301
745-750
2003
Aspergillus niger
Kojima, M.; Tanokura, M.; Maeda, M.; Kimura, K.; Amemiya, Y.; Kihara, H.; Takahashi, K.
pH-dependent unfolding of aspergillopepsin II studied by small-angle X-ray scattering
Biochemistry
39
1364-1372
2000
Aspergillus niger
Takahashi, K.
The specificity of peptide bond cleavage of acid proteinase A from Aspergillus niger var. macrosporus toward oxidized ribonuclease A
Biosci. Biotechnol. Biochem.
61
381-383
1997
Aspergillus niger
Huang, X.P.; Kagami, N.; Inoue, H.; Kojima, M.; Kimura, T.; Makabe, O.; Suzuki, K.; Takahashi, K.
Identification of a glutamic acid and an aspartic acid residue essential for catalytic activity of aspergillopepsin II, a non-pepsin type acid proteinase
J. Biol. Chem.
275
26607-26614
2000
Aspergillus niger
Yabuki, Y.; Kubota, K.; Kojima, M.; Inoue, H.; Takahashi, K.
Identification of a glutamine residue essential for catalytic activity of aspergilloglutamic peptidase by site-directed mutagenesis
FEBS Lett.
569
161-164
2004
Aspergillus niger var. macrosporus
Takahashi, K.
Aspergillopepsin II
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
221-224
2004
Aspergillus niger var. macrosporus
-
Kubota, K.; Nishii, W.; Kojima, M.; Takahashi, K.
Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide
J. Biol. Chem.
280
999-1006
2005
Aspergillus niger var. macrosporus
Sasaki, H.; Nakagawa, A.; Muramatsu, T.; Suganuma, M.; Sawano, Y.; Kojima, M.; Kubota, K.; Takahashi, K.; Tanokura, M.
The three-dimensional structure of aspergilloglutamic peptidase from Aspergillus niger
Proc. Jpn. Acad. Ser. B
80
435-438
2004
Aspergillus niger var. macrosporus
-
Sasaki, H.; Kojima, M.; Sawano, Y.; Kubota, K.; Suganuma, M.; Muramatsu, T.; Takahashi, K.; Tanokura, M.
A proposed catalytic mechanism of aspergilloglutamic peptidase from Aspergillus niger
Proc. Jpn. Acad. Ser. B
81
441-446
2005
Aspergillus niger var. macrosporus
-
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