3.4.21.83: Oligopeptidase B

This is an abbreviated version!
For detailed information about Oligopeptidase B, go to the full flat file.

Word Map on EC 3.4.21.83

3.4.21.83

gingivalis

prolyl

leupeptin

chymotrypsin-like

antipain

porphyromonas

aprotinin

chloromethyl

chymostatin

tlck

tryptase

2-macroglobulin

benzamidine

acrosin

phenylmethanesulfonyl

proteamaculans

bapna

drug development

medicine

Reaction

Hydrolysis of -Arg-/-, -Lys-/- bonds in oligopeptides, even when P1' residue is proline =

Synonyms

La_OpB, oligopeptidase B, oligopeptidase B-like, oligopeptidase B2, OP-Tb, OPB, OPB2, OPBTc, Opd B, OpdB, Protease II, Proteinase, Escherichia coli alkaline, II, PSP, Spro_3467, Tb-OP, Tc 120, Tc-OP, trypsin-like protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.83 Oligopeptidase B

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Results	in table
11	Activating Compound
5059	AA Sequence
3	Application
1	CAS Registry Number
24	Cloned(Commentary)
5	Crystallization (Commentary)
19	General Information
4	General Stability
1	IC50 Value
99	Inhibitors
86	kcat/KM [mM/s]
30	Ki Value [mM]
344	KM Value [mM]
3	Localization
5	Metals/Ions
20	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
55	Organism
9	PDB ID
17	pH Optimum
6	pH Range
3	pH Stability
2	pI Value
2	Posttranslational Modification
69	Protein Variants
16	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
7	Source Tissue
62	Specific Activity [micromol/min/mg]
4	Storage Stability
384	Substrates and Products (Substrate)
15	Subunits
64	Synonyms
17	Temperature Optimum [°C]
4	Temperature Range [°C]
14	Temperature Stability [°C]
332	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.21.83 - Oligopeptidase B

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Aprotinin

Xenorhabdus nematophila

0.3 microM, 103% activity

663686

bestatin

Xenorhabdus nematophila

0.13 mM, 105% activity

cysteine

dithiothreitol

E-64

Xenorhabdus nematophila

5 microM, 114% activity

glutathione

leupeptin

Xenorhabdus nematophila

1 microM, 116% activity

663686

NaCl

Streptomyces griseus

enzymatic activity is markedly enhanced by high NaCl concentration, NaCl affects the P1 preference of OpdB synergistically in a substrate-dependent manner

707565

oxidized glutathione

Streptomyces griseus

oxidized glutathione enhances OpdB activity and affects the P1 preference of OpdB synergistically in a substrate-dependent manner

707565

reduced glutathione

Streptomyces griseus

enzymatic activity is markedly enhanced by reduced glutathione at submillimolar level which affects the P1 preference of OpdB synergistically in a substrate-dependent manner

707565