3.4.21.83: Oligopeptidase B

This is an abbreviated version!
For detailed information about Oligopeptidase B, go to the full flat file.

Word Map on EC 3.4.21.83

Reaction

Hydrolysis of -Arg-/-, -Lys-/- bonds in oligopeptides, even when P1' residue is proline =

Synonyms

Proteinase, Escherichia coli alkaline, II, Protease II, PSP, OpdB, Tb-OP, Tc-OP, oligopeptidase B, La_OpB, OP-Tb, Opd B, Tc 120, OPB, trypsin-like protease, OPBTc, Spro_3467, oligopeptidase B2, oligopeptidase B-like, OPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.83 Oligopeptidase B

Activating Compound

Activating Compound on EC 3.4.21.83 - Oligopeptidase B

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Aprotinin
-
0.3 microM, 103% activity
bestatin
-
0.13 mM, 105% activity
dithiothreitol
E-64
-
5 microM, 114% activity
leupeptin
-
1 microM, 116% activity
NaCl
-
enzymatic activity is markedly enhanced by high NaCl concentration, NaCl affects the P1 preference of OpdB synergistically in a substrate-dependent manner
oxidized glutathione
-
oxidized glutathione enhances OpdB activity and affects the P1 preference of OpdB synergistically in a substrate-dependent manner
reduced glutathione
-
enzymatic activity is markedly enhanced by reduced glutathione at submillimolar level which affects the P1 preference of OpdB synergistically in a substrate-dependent manner