Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase

This is an abbreviated version!
For detailed information about serine-type D-Ala-D-Ala carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.16.4

Reaction

Preferential cleavage: (Ac)2-L-Lys-D-Ala-/-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine =

Synonyms

carboxypeptidase I, CPase, D,D-carboxypeptidase, D,D-carboxypeptidase R39, D,D-dipeptidase, D-Ala-D-Ala carboxypeptidase, D-Ala-D-Ala peptidase, D-Ala-D-Ala(D,D) carboxypeptidase, D-alanine carboxypeptidase, D-alanine carboxypeptidase I, D-alanine-carboxypeptidase, D-alanyl carboxypeptidase, D-alanyl-D-alanine carboxypeptidase, D-alanyl-D-alanine carboxypeptidase/transpeptidase, D-Alanyl-D-alanine hydrolase, D-alanyl-D-alanine peptidase, D-alanyl-D-alanine transpeptidase, D-alanyl-D-alanine-carboxypeptidase, D-alanyl-D-alanine-cleaving peptidase, D-alanyl-D-alanine-cleaving-peptidase, D-alanyl-D-alanine-transpeptidase, D-amino acid amidase, DAA, Dac, dacA, DacA-1, DacB, DacC, DacD, DAP, Dbv7, DD-Carboxypeptidase, DD-CPase, DD-CPase1, DD-peptidase, DD-transpeptidase, DD-transpeptidase/penicillin-binding protein, LMM-PBP, low molecular mass penicillin binding protein, PBP, PBP 2, PBP 3, PBP 4, PBP 5, PBP 6, PBP-5*, PBP-6B, PBP1a, PBP1b, PBP2x, PBP3, PBP4, PBP4a, PBP5, PBP6, PBP6a, PBP6b, penicillin binding protein 4, penicillin binding protein 5, penicillin binding proteins, penicillin-binding protein, penicillin-binding protein 1B, penicillin-binding protein 4a, penicillin-binding protein 5, penicillin-binding protein 5a, R39 PBP, SCO4439, serine type D-alanyl-D-alanine carboxypeptidase/transpeptidase, serine-type D-Ala-D-Ala carboxypeptidase, serine-type-D-Ala-D-Ala carboxypeptidase, transpeptidase, VanX, VanXY, VanY, VanY(D) DD-carboxypeptidase, VanYD, VanYn, VC_0947, VP2468, zinc D-Ala-D-Ala carboxypeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase

KM Value

KM Value on EC 3.4.16.4 - serine-type D-Ala-D-Ala carboxypeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
(2R)-2-[[N-(phenylacetyl)glycyl]sulfanyl]propanoic acid
-
-
0.86
2-(N-glycyl-L-cysteinyl)acetyl-D-alanyl-D-alanine
-
-
1.28
3-(N-acetyl-L-cysteinyl)propanoyl-D-alanyl-D-alanine
-
-
3
3-(N-glycyl-cysteaminyl)propanoyl-D-alanyl-D-alanine
-
-
0.004
3-(N-glycyl-L-cysteinyl)-propanoyl-D-alanyl-D-thiolactate
-
-
0.48
3-(N-glycyl-L-cysteinyl)butanoyl-D-alanyl-D-alanine
-
-
0.26
3-(N-glycyl-L-cysteinyl)propanoyl-D-alanyl-D-alanine
-
-
0.36 - 4.3
3-carboxyphenyl (2R)-N-(phenylacetyl)-2-hydroxyglycinate
0.2 - 0.45
3-carboxyphenyl (2R)-N-(phenylacetyl)-2-methoxyglycinate
0.2 - 0.45
3-carboxyphenyl N-(phenylacetyl)-alpha-methoxyglycinate
0.35 - 1.8
3-carboxyphenyl N-(phenylacetyl)-alpha-serinate
1.37
3-[[N-(phenylacetyl)-D-alanyl]oxy]benzoic acid
-
-
0.76
3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid
-
-
7.5
acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala-D-Ala
-
-
8
acetyl-L-Lys-D-Ala-D-Ala
pH 7.4, 25°C
1.3 - 1.5
benzoyl-D-Ala-thioglycolate
0.8 - 3
benzoyl-Gly-thioglycolate
0.22 - 1
benzoyl-Gly-thiolactate
6.4
Boc-gamma-D-Glu-L-Lys-(Cbz)-D-Ala-D-Ala
-
20
D-Ala-D-Ala
pH 7.4, 25°C
0.86
Gly-gamma-L-Glu-D-Ala-D-Ala
-
-
0.0079
Gly-L-alpha-amino-epsilon-pimelyl-D-Ala-D-Ala
-
-
0.0079
glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine
-
-
0.26
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]amino]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine
-
-
0.0041
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine
-
-
0.12
hippuryl-mercaptoacetic acid
-
crystal and solution
1.38
L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala
-
recombinant PBP 5, in 50 mM Tris-HCl, pH 8.5, at 37°C
9.8
N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine
-
-
3.5
N-(N-acetyl-1-O-methyl-beta-muramoyl)-L-alanyl-D-gamma-glutamyl-L-lysyl-D-alanyl-D-alanine
-
pH 7.5, 25°C
0.675 - 0.913
N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
0.0178 - 0.401
N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine
0.4
N-alpha-acetyl-L-Lys-D-Ala-thiolactate
pH 7.2, 37°C, wild-type enzyme
0.0079
N-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine
-
-
3.7
N-[N-acetyl-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-1-O-methyl-beta-muramoyl]-L-alanyl-D-gamma-glutamyl-L-lysyl-D-alanyl-D-alanine
-
pH 7.5, 25°C
12
Nalpha, Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala
-
lysozyme releasable enzyme
0.1 - 14
Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala
2 - 3
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-thiolactate
1.45
Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala-D-Ala
-
-
9.4 - 30
Nalpha-Acetyl-L-Lys-D-Ala-D-Ala
0.6
Nalpha-acetyl-L-Lys-D-Ala-thiolactate
pH 7.2, 37°C, mutant enzyme C98A
2.4 - 3
phenylacetyl-D-Ala-thioglycolate
1.2
phenylacetyl-D-Ala-thiolactate
1.4
UDP-N-acetylmuramyl-L-Ala-D-Glu-mesodiaminopimelyl-D-Ala-D-Ala
-
-
5 - 20
X-D-Ala-D-Ala
-
value depending on X
additional information
additional information
-