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Literature summary for 3.4.16.4 extracted from
- Deacylation transition states of a bacterial DD-peptidase (2006), Biochemistry, 45, 13074-13082.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | DD-peptidases are targets for antibiotic designs | Streptomyces sp. R61 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-alpha-phenylpropionate | - |
Streptomyces sp. R61 |  |
| D-hexahydromandelate | - |
Streptomyces sp. R61 | |
| D-mandelate | - |
Streptomyces sp. R61 | |
| D-phenyllactate | - |
Streptomyces sp. R61 | |
| glycolyl-L-Phe | - |
Streptomyces sp. R61 | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0041 | - |
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | - |
Streptomyces sp. R61 | |
| 0.0079 | - |
N-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine | - |
Streptomyces sp. R61 | |
| 0.26 | - |
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]amino]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | - |
Streptomyces sp. R61 | |
| 0.76 | - |
3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid | - |
Streptomyces sp. R61 | |
| 1 | - |
(2R)-2-[[N-(phenylacetyl)glycyl]sulfanyl]propanoic acid | - |
Streptomyces sp. R61 | |
| 1.37 | - |
3-[[N-(phenylacetyl)-D-alanyl]oxy]benzoic acid | - |
Streptomyces sp. R61 | |
| 9.8 | - |
N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine | - |
Streptomyces sp. R61 | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces sp. R61 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2R)-2-[[N-(phenylacetyl)glycyl]sulfanyl]propanoic acid + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| 3-[[N-(phenylacetyl)-D-alanyl]oxy]benzoic acid + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| 3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]amino]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
| N-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine + H2O | - |
Streptomyces sp. R61 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DD-peptidase | - |
Streptomyces sp. R61 |
| PBP | - |
Streptomyces sp. R61 |
| penicillin-binding protein | - |
Streptomyces sp. R61 |
| transpeptidase | - |
Streptomyces sp. R61 |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
kinetic measurements | Streptomyces sp. R61 |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.51 | - |
3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid | - |
Streptomyces sp. R61 | |
| 5.7 | - |
(2R)-2-[[N-(phenylacetyl)glycyl]sulfanyl]propanoic acid | - |
Streptomyces sp. R61 | |
| 31 | - |
3-[[N-(phenylacetyl)-D-alanyl]oxy]benzoic acid | - |
Streptomyces sp. R61 | |
| 34.5 | - |
N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine | - |
Streptomyces sp. R61 | |
| 48 | - |
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]amino]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | - |
Streptomyces sp. R61 | |
| 69 | - |
N-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine | - |
Streptomyces sp. R61 | |
| 81 | - |
glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | - |
Streptomyces sp. R61 | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
kinetic measurements | Streptomyces sp. R61 |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7 | - |
D-hexahydromandelate | substrate glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | Streptomyces sp. R61 | |
| 11.6 | - |
D-mandelate | substrate (2R)-2-[[N-(phenylacetyl)glycyl]sulfanyl]propanoic acid | Streptomyces sp. R61 | |
| 11.6 | - |
D-mandelate | substrate 3-[[N-(phenylacetyl)-D-alanyl]oxy]benzoic acid | Streptomyces sp. R61 | |
| 11.6 | - |
D-mandelate | substrate 3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid | Streptomyces sp. R61 | |
| 11.6 | - |
D-mandelate | substrate glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | Streptomyces sp. R61 | |
| 15.5 | - |
D-alpha-phenylpropionate | glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | Streptomyces sp. R61 | |
| 17.8 | - |
D-phenyllactate | substrate glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | Streptomyces sp. R61 | |
| 19.3 | - |
glycolyl-L-Phe | substrate glycyl-S-(3-[[(1R)-2-[[(1R)-1-carboxyethyl]sulfanyl]-1-methyl-2-oxoethyl]amino]-3-oxopropyl)-L-cysteine | Streptomyces sp. R61 | |
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