1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.

Word Map on EC 1.3.99.5

Reaction

a 3-oxo-5alpha-steroid
+
acceptor
=
a 3-oxo-DELTA4-steroid
+
reduced acceptor

Synonyms

dehydrogenase, 3-oxo-5alphasteroid DELTA4-, steroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, steroid DELTA4-5alpha-reductase, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-oxo steroid reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxosteroid-5alpha-reductase, 3-keto-DELTA4-steroid-5 alpha-reductase, 5alpha-reductase, testosterone 5alpha-reductase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, DELTA4-5alpha-dehydrogenase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, DELTA4(5alpha)DH, 5 alpha-SR2, S5AR, 5alpha-R, steroid 5alpha-reductase type 1, 5alpha-R1, S5alphaRI, S5alphaRII, SRD5A1, SRD5A2, 5alphaR1, 5alphaR2, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5-alpha reductase II, type 2 5alpha-reductase, type 1 5alpha-reductase, 5alpha-reductase type II, steroid 5alpha-reductase type 2, steroid-5alpha-reductase, SRD5alpha, 5alpha-reductase type1, 5alpha-reductase type2, type II 5alpha-reductase, 5AR2, 3-oxo-steroid-4-ene dehydrogenase, type I 5alpha-reductase, NADPH-dependent 5alpha-reductase enzyme, steroid 5-alpha reductase type 2, r5alphaR1, steroid 5-alpha-reductase type 2, 5alpha reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

KI Value

KI Value on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
(10bR)-8-chloro-4,10b-dimethyl-1,5,6,10b-tetrahydrophenanthridin-3(2H)-one
pH not specified in the publication, temperature not specified in the publication
0.0011
(10bR)-8-chloro-4,5,10b-trimethyl-1,5,6,10b-tetrahydrophenanthridin-3(2H)-one
pH not specified in the publication, temperature not specified in the publication
0.00092
(10bR)-8-chloro-5,10b-dimethyl-1,5,6,10b-tetrahydrophenanthridin-3(2H)-one
pH not specified in the publication, temperature not specified in the publication
0.000036
(17beta)-17-(propan-2-ylcarbamoyl)estra-1(10),2,4,6,8-pentaene-3-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.00003
(17beta)-17-(propan-2-ylcarbamoyl)estra-1(10),2,4,6-tetraene-3-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.00002
(17beta)-17-(propan-2-ylcarbamoyl)estra-1(10),2,4-triene-3-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.000035
(17beta)-2-chloro-17-(propan-2-ylcarbamoyl)estra-1(10),2,4-triene-3-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.00001
(17beta)-4-fluoro-17-(propan-2-ylcarbamoyl)estra-1(10),2,4-triene-3-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.00098
(4R)-5,10-seco-19-nor-pregna-4,5-diene-3,10,20-trione
pH not specified in the publication, temperature not specified in the publication
0.00547
(4R)-5,10-seco-estra-4,5-diene-3,10,17-trione
pH not specified in the publication, temperature not specified in the publication
0.000104
(6aS,7S)-6a-methyl-N-(propan-2-yl)-5,6,6a,7,8,9,9a,9b-octahydro-4bH-indeno[5,4-f]isoquinoline-7-carboxamide 2-oxide
pH not specified in the publication, temperature not specified in the publication
0.000031
(6aS,7S)-N,N-diethyl-6a-methyl-5,6,6a,7,8,9,9a,9b-octahydro-4bH-indeno[5,4-f]isoquinoline-7-carboxamide 2-oxide
pH not specified in the publication, temperature not specified in the publication
0.0016 - 0.0019
(7-chloro-3,4,4a,9-tetrahydrophenanthren-2-yl)phosphinic acid
0.0014
16-ethyl-17beta-hydroxy-4-estren-3-one
-
pH not specified in the publication, temperature not specified in the publication
0.00009
6-[3-(N,N-dicyclohexylaminocarbonyl)phenyl]-3,4-dihydro-naphthalene-2-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.00009
6-[4-(N,N-diisopropylamino-carbonyl)phenyl]naphthalene-2-carboxylic acid
pH not specified in the publication, temperature not specified in the publication
0.0008
6-[4-(N,N-diisopropylcarbamoyl) phenyl]-1H-quinolin-2-one
pH not specified in the publication, temperature not specified in the publication
0.00051
6-[4-(N,N-diisopropylcarbamoyl) phenyl]-N-methyl-quinolin-2-one
pH not specified in the publication, temperature not specified in the publication
0.000026 - 0.01
7-bromo-9,10-dihydrophenanthrene-2-carboxylic acid
0.00026 - 0.0012
7-chloro-3,4,4a,9-tetrahydrophenanthrene-2-carboxylic acid
0.00032 - 0.0025
7-chloro-9,10-dihydrophenanthrene-2-carboxylic acid
0.000315 - 0.01
9,10-dihydrophenanthrene-2-carboxylic acid