1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.

Word Map on EC 1.3.99.5

Reaction

a 3-oxo-5alpha-steroid
+
acceptor
=
a 3-oxo-DELTA4-steroid
+
reduced acceptor

Synonyms

dehydrogenase, 3-oxo-5alphasteroid DELTA4-, steroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, steroid DELTA4-5alpha-reductase, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-oxo steroid reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxosteroid-5alpha-reductase, 3-keto-DELTA4-steroid-5 alpha-reductase, 5alpha-reductase, testosterone 5alpha-reductase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, DELTA4-5alpha-dehydrogenase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, DELTA4(5alpha)DH, 5 alpha-SR2, S5AR, 5alpha-R, steroid 5alpha-reductase type 1, 5alpha-R1, S5alphaRI, S5alphaRII, SRD5A1, SRD5A2, 5alphaR1, 5alphaR2, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5-alpha reductase II, type 2 5alpha-reductase, type 1 5alpha-reductase, 5alpha-reductase type II, steroid 5alpha-reductase type 2, steroid-5alpha-reductase, SRD5alpha, 5alpha-reductase type1, 5alpha-reductase type2, type II 5alpha-reductase, 5AR2, 3-oxo-steroid-4-ene dehydrogenase, type I 5alpha-reductase, NADPH-dependent 5alpha-reductase enzyme, steroid 5-alpha reductase type 2, r5alphaR1, steroid 5-alpha-reductase type 2, 5alpha reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

Engineering

Engineering on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Y235F
-
the mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
G196S
-
the mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
C133G
-
the mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
A207D
-
the mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
W53X
-
the nonsense mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
G34W
-
the mutation is associated with the occurrence of steroid 5alpha-reductase deficiency
R246Q
frequent naturally occuring mutation of SRD5A2 involved in the SRD deficiency syndrome
G203S
naturally occuring mutation of SRD5A2 involved in the SRD deficiency syndrome
W136A
no residual activity
Y319F
no residual activity
Y466A
no residual activity
Y466F
no residual activity
W136F
about 40% of wild-type catalytic efficiency
S468T
about 65% of wild-type catalytic efficiency
S468A
no residual activity
additional information