1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.

Reaction

Synonyms

3-keto-DELTA4-steroid-5 alpha-reductase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, 3-oxo-steroid-4-ene dehydrogenase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, 5 alpha-SR2, 5-alpha reductase II, 5alpha reductase, 5alpha-R, 5alpha-R1, 5alpha-reductase, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-reductase type1, 5alpha-reductase type2, 5alphaR1, 5alphaR2, 5AR2, dehydrogenase, 3-oxo-5alphasteroid DELTA4-, DELTA4(5alpha)DH, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxo steroid reductase, DELTA4-3-oxosteroid-5alpha-reductase, DELTA4-5alpha-dehydrogenase, NADPH-dependent 5alpha-reductase enzyme, r5alphaR1, S5alphaRI, S5alphaRII, S5AR, SRD5A1, SRD5A2, SRD5alpha, steroid 5-alpha reductase type 2, steroid 5-alpha-reductase type 2, steroid 5alpha-reductase, steroid 5alpha-reductase type 1, steroid 5alpha-reductase type 2, steroid DELTA4-5alpha-reductase, steroid-5alpha-reductase, testosterone 5alpha-reductase, type 1 5alpha-reductase, type 2 5alpha-reductase, type I 5alpha-reductase, type II 5alpha-reductase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.99 With unknown physiological acceptors

                1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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Results	in table
5	Activating Compound
210	AA Sequence
7	Application
1	CAS Registry Number
16	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
2406	Disease/ Diagnostics
2	Expression
17	General Information
392	IC50 Value
561	Inhibitors
3	kcat/KM [mM/s]
27	Ki Value [mM]
9	KM Value [mM]
6	Localization
2	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
54	Organism
4	Pathway
2	PDB ID
11	pH Optimum
1	pH Range
23	Protein Variants
1	Reaction
3	Reaction Type
54	Reference
66	Source Tissue
2	Specific Activity [micromol/min/mg]
45	Substrates and Products (Substrate)
2	Subunits
84	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5alpha-dihydrotestosterone + NADP+

testosterone + NADPH + H+

3 entries

5alpha-pregn-3,20-dione + NADP+

progesterone + NADPH + H+

Anolis carolinensis

-

5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone

712093

-

-

r

deoxycorticosterone + reduced acceptor

21-hydroxy-5alpha-pregnan-3,20-dione + acceptor

Rattus norvegicus

-

-

655526

-

-

?

dihydrotestosterone + NADP+

testosterone + NADPH + H+

3 entries

progesterone + reduced acceptor

5alpha-pregnan-3,20-dione + acceptor

Mus musculus

-

-

662726

-

-

?

progesterone + reduced acceptor

pregnane-3,20-dione + acceptor

Rattus norvegicus

-

-

655526

-

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

6 entries

additional information

?

-

2 entries

5alpha-dihydrotestosterone + NADP+

testosterone + NADPH + H+

Anolis carolinensis

-

5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone

712093

-

-

r

5alpha-dihydrotestosterone + NADP+

testosterone + NADPH + H+

Homo sapiens

-

the enzyme performs conversion of testosterone to 5alpha-dihydrotestosterone

713520

-

-

r

5alpha-dihydrotestosterone + NADP+

testosterone + NADPH + H+

Homo sapiens

P18405, P31213

the enzyme performs conversion of testosterone to 5alpha-dihydrotestosterone

713519

-

-

r

dihydrotestosterone + NADP+

testosterone + NADPH + H+

Homo sapiens

-

the enzyme performs conversion of testosterone to dihydrotestosterone

713080

-

-

r

dihydrotestosterone + NADP+

testosterone + NADPH + H+

Mesocricetus auratus

C7T2J7, C7T2J8

the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone

712094

-

-

r

dihydrotestosterone + NADP+

testosterone + NADPH + H+

Rattus norvegicus

-

the enzyme performs conversion of testosterone to dihydrotestosterone

711736

-

-

r

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Comamonas testosteroni

-

key enzyme in the degradation of steroids having an A:B ring fusion in a trans configuration

391399

-

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Homo sapiens

-

-

688720, 740177, 740834, 740982

-

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Mus musculus

-

-

662726

-

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Rattus norvegicus

-

-

655346, 740834

-

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Rattus norvegicus

-

-

655526

5alpha-dihydrotestosterone is a more potent androgen

-

?

testosterone + reduced acceptor

5alpha-dihydrotestosterone + acceptor

Rattus norvegicus

-

enzyme plays a key role in androgen-dependent target tissues, where it catalyzes the conversion of testosterone to the biologically active dihydrotestosterone, transcriptional control of 5alpha-reductase expression

391397

-

-

?

additional information

?

-

Rattus norvegicus

-

neonatal testicular androgens, e.g. testosterone, irreversibly program several hepatic enzyme activities in the rat including 5alpha-reductase, tissue-specific physiological regulation of isozymes

655346

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview

655526

-

-

?