1.3.1.B13: polyprenol reductase (NADPH)

This is an abbreviated version!
For detailed information about polyprenol reductase (NADPH), go to the full flat file.

Word Map on EC 1.3.1.B13

Reaction

a dolichol
+
NADP+
=
a polyprenol
+
NADPH
+
H+

Synonyms

polyprenol reductase, polyprenol reductase 1, polyprenol reductase 2, polyprenol reductase2, PPRD1, PPRD2, SRD5A3

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.B13 polyprenol reductase (NADPH)

Engineering

Engineering on EC 1.3.1.B13 - polyprenol reductase (NADPH)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H321L
site-directed mutagenesis, the mutant shows 47% of wild-type reductase activity
H336L
site-directed mutagenesis, the mutant shows 45% of wild-type reductase activity
H321L
-
site-directed mutagenesis, the mutant shows 47% of wild-type reductase activity
-
H336L
-
site-directed mutagenesis, the mutant shows 45% of wild-type reductase activity
-
H296G
inactive mutant enzyme, shows no reduction of polyprenol
additional information