1.3.1.B13: polyprenol reductase (NADPH)

This is an abbreviated version!
For detailed information about polyprenol reductase (NADPH), go to the full flat file.

Word Map on EC 1.3.1.B13

Reaction

a dolichol
+
NADP+
=
a polyprenol
+
NADPH
+
H+

Synonyms

polyprenol reductase, polyprenol reductase 1, polyprenol reductase 2, polyprenol reductase2, PPRD1, PPRD2, SRD5A3

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.B13 polyprenol reductase (NADPH)

Reference

Reference on EC 1.3.1.B13 - polyprenol reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantagrel, V.; Lefeber, D.J.; Ng, B.G.; Guan, Z.; Silhavy, J.L.; Bielas, S.L.; Lehle, L.; Hombauer, H.; Adamowicz, M.; Swiezewska, E.; De Brouwer, A.P.; Bluemel, P.; Sykut-Cegielska, J.; Houliston, S.; Swistun, D.; Ali, B.R.; Dobyns, W.B.; Babovic-Vuksanovic, D.; van Bokhoven, H.; Wevers, R.A.; Raetz, C.
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
Cell
142
203-217
2010
Homo sapiens (Q9H8P0)
Manually annotated by BRENDA team
Wheeler, P.G.; Ng, B.G.; Sanford, L.; Sutton, V.R.; Bartholomew, D.W.; Pastore, M.T.; Bamshad, M.J.; Kircher, M.; Buckingham, K.J.; Nickerson, D.A.; Shendure, J.; Freeze, H.H.
SRD5A3-CDG Expanding the phenotype of a congenital disorder of glycosylation with emphasis on adult onset features
Am. J. Med. Genet. A
170
3165-3171
2016
Homo sapiens (Q9H8P0)
Manually annotated by BRENDA team
Jozwiak, A.; Gutkowska, M.; Gawarecka, K.; Surmacz, L.; Buczkowska, A.; Lichocka, M.; Nowakowska, J.; Swiezewska, E.
Polyprenol reductase2 deficiency is lethal in Arabidopsis due to male sterility
Plant Cell
27
3336-3353
2015
no activity in Escherichia coli, Arabidopsis thaliana (Q9CAH5), Arabidopsis thaliana (Q9SI62), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9CAH5), Arabidopsis thaliana Col-0 (Q9SI62)
Manually annotated by BRENDA team