1.3.1.85: crotonyl-CoA carboxylase/reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.

Word Map on EC 1.3.1.85

Reaction

(2S)-ethylmalonyl-CoA
+
NADP+
=
(E)-but-2-enoyl-CoA
+
CO2
+
NADPH
+
H+

Synonyms

2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, pteB, rimJ

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.85 crotonyl-CoA carboxylase/reductase

Engineering

Engineering on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A182G
-
inactive
A182L
-
the mutant with increased activity selectively catalyzes carboxylation over the regular reduction reaction
V350A
-
the mutant shows increased activity compared to the wild type enzyme
V350F
-
the mutant shows increased activity compared to the wild type enzyme
V350G
-
the mutant shows increased activity compared to the wild type enzyme
A182G
-
inactive
-
A182L
-
the mutant with increased activity selectively catalyzes carboxylation over the regular reduction reaction
-
V350A
-
the mutant shows increased activity compared to the wild type enzyme
-
V350F
-
the mutant shows increased activity compared to the wild type enzyme
-
V350G
-
the mutant shows increased activity compared to the wild type enzyme
-