1.3.1.85: crotonyl-CoA carboxylase/reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.

Word Map on EC 1.3.1.85

Reaction

(2S)-ethylmalonyl-CoA
+
NADP+
=
(E)-but-2-enoyl-CoA
+
CO2
+
NADPH
+
H+

Synonyms

2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, pteB, rimJ

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.85 crotonyl-CoA carboxylase/reductase

Substrates Products

Substrates Products on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E)-3-cyclohexylprop-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-3-cyclohexylpropanoyl-CoA + NADP+
show the reaction diagram
(2E)-4-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
[(2R)-2-methylbutyl]propanedioyl-CoA + NADP+
show the reaction diagram
(2E)-5-chloropent-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-5-chloropentanoyl-CoA + NADP+
show the reaction diagram
(2E)-5-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-(3-methylbutyl)propanedioyl-CoA + NADP+
show the reaction diagram
(2E)-6-methyloct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-6-methyloctanoyl-CoA + NADP+
show the reaction diagram
-
-
-
?
(2E)-hept-2-en-6-ynoyl-CoA + NADPH + CO2 + H+
(2S)-2-craboxy-hept-6-ynoyl-CoA + NADP+
show the reaction diagram
-
-
-
?
(2E)-hex-2-enoyl-CoA + NADPH + CO2 + H+
(S)-2-butylpropanedioyl-CoA + NADP+
show the reaction diagram
-
-
-
?
(2E)-oct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxyoctanoyl-CoA + NADP+
show the reaction diagram
(E)-crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
show the reaction diagram
-
100% relative specific activity, the carboxylation reaction is the physiologically relevant reaction
-
-
r
(E)-crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
show the reaction diagram
-
10% of maximal activity (compared with vmax of crotonyl-CoA carboxylation)
-
-
?
3-indolylacryloyl-CoA + NADPH + CO2 + H+
indolylmethylmalonyl-CoA + NADP+
show the reaction diagram
4-coumaroyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-(4-hydroxyphenyl)propionyl-CoA + NADP+
show the reaction diagram
acryloyl-CoA + CO2 + NADPH + H+
methylmalonyl-CoA + NADP+
show the reaction diagram
-
acryloyl-CoA is accepted as an alternative substrate analogue by the enzyme with 40% relative activity (compared with vmax of crotonyl-CoA carboxylation)
-
-
?
cinnamoyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-phenylpropionyl-CoA + NADP+
show the reaction diagram
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
show the reaction diagram
crotonyl-CoA + CO2 + NADPH + H+
?
show the reaction diagram
crotonyl-CoA + NADPH + CO2 + H+
(2S)-ethylmalonyl-CoA + NADP+
show the reaction diagram
crotonyl-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
show the reaction diagram
decanoyl-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
?
hexanoyl-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
?
octanoyl-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
?
additional information
?
-