1.3.1.85: crotonyl-CoA carboxylase/reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.

Word Map on EC 1.3.1.85

Reaction

(2S)-ethylmalonyl-CoA
+
NADP+
=
(E)-but-2-enoyl-CoA
+
CO2
+
NADPH
+
H+

Synonyms

2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, pteB, rimJ

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.85 crotonyl-CoA carboxylase/reductase

Reference

Reference on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Erb, T.J.; Berg, I.A.; Brecht, V.; Mueller, M.; Fuchs, G.; Alber, B.E.
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway
Proc. Natl. Acad. Sci. USA
104
10631-10636
2007
Methylorubrum extorquens AM1, Rhodobacter sphaeroides 2.4.1, Streptomyces coelicolor
Manually annotated by BRENDA team
Alber, B.E.
Biotechnological potential of the ethylmalonyl-CoA pathway
Appl. Microbiol. Biotechnol.
89
17-25
2010
Methylorubrum extorquens, Rhodobacter sphaeroides, Streptomyces coelicolor
Manually annotated by BRENDA team
Erb, T.J.; Brecht, V.; Fuchs, G.; Muller, M.; Alber, B.E.
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
Proc. Natl. Acad. Sci. USA
106
8871-8876
2009
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Yoo, H.G.; Kwon, S.Y.; Kim, S.; Karki, S.; Park, Z.Y.; Kwon, H.J.
Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis
Biosci. Biotechnol. Biochem.
75
1191-1193
2011
Streptomyces avermitilis (Q79ZT3), Streptomyces avermitilis
Manually annotated by BRENDA team
Schneider, K.; Asao, M.; Carter, M.S.; Alber, B.E.
Rhodobacter sphaeroides uses a reductive route via propionyl coenzyme A to assimilate 3-hydroxypropionate
J. Bacteriol.
194
225-232
2012
Rhodobacter sphaeroides (B8XVS5), Rhodobacter sphaeroides
Manually annotated by BRENDA team
Hu, B.; Lidstrom, M.
CcrR, a TetR family transcriptional regulator, activates the transcription of a gene of the Ethylmalonyl coenzyme A pathway in Methylobacterium extorquens AM1
J. Bacteriol.
194
2802-2808
2012
Methylorubrum extorquens, Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
Manually annotated by BRENDA team
Zhang, L.; Chen, J.; Mori, T.; Yan, Y.; Liu, W.; Abe, I.
Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288
Acta Crystallogr. Sect. F
70
734-737
2014
Streptomyces sp. (M1SQA1), Streptomyces sp. NRRL 2288 (M1SQA1)
Manually annotated by BRENDA team
Zhang, L.; Mori, T.; Zheng, Q.; Awakawa, T.; Yan, Y.; Liu, W.; Abe, I.
Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Angew. Chem. Int. Ed. Engl.
54
13462-13465
2015
Streptomyces sp. (M1SQA1), Streptomyces sp. NRRL 2288 (M1SQA1)
Manually annotated by BRENDA team
Blazic, M.; Kosec, G.; Baebler, S.; Gruden, K.; Petkovic, H.
Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis
Microb. Cell Fact.
14
164
2015
Streptomyces tsukubensis, Streptomyces tsukubensis NRRL 18488
Manually annotated by BRENDA team
Ray, L.; Valentic, T.R.; Miyazawa, T.; Withall, D.M.; Song, L.; Milligan, J.C.; Osada, H.; Takahashi, S.; Tsai, S.C.; Challis, G.L.
A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
Nat. Commun.
7
13609
2016
Streptomyces ambofaciens, Streptomyces ambofaciens ATCC23877
Manually annotated by BRENDA team
Escudero, L.; Al-Refai, M.; Nieto, C.; Laatsch, H.; Malpartida, F.; Seco, E.M.
New rimocidin/CE-108 derivatives obtained by a crotonyl-CoA carboxylase/reductase gene disruption in Streptomyces diastaticus var. 108: substrates for the polyene carboxamide synthase PcsA
PLoS ONE
10
e0135891
2015
Streptomyces diastaticus (Q6T2B7), Streptomyces diastaticus
Manually annotated by BRENDA team