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Information on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

for references in articles please use BRENDA:EC1.3.1.85

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IUBMB Comments

The reaction is catalysed in the reverse direction. This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyses (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2. When CO2 is absent, the enzyme catalyses the reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).

The enzyme appears in viruses and cellular organisms

Synonyms
crotonyl-coa carboxylase/reductase, 2-octenoyl-coa carboxylase/reductase, enoyl-coa carboxylase/reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-ethylmalonyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + CO2 + NADPH + H+
show the reaction diagram
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