1.14.15.22: vitamin D 1,25-hydroxylase

This is an abbreviated version, for detailed information about vitamin D 1,25-hydroxylase, go to the full flat file.

Reaction

calcidiol
+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ +
O2
=
calcitriol
+ 2 oxidized ferredoxin [iron-sulfur] cluster +
H2O

Synonyms

CYP105A1, cytochrome P450SU-1, Streptomyces griseolus cytochrome P450SU-1, vitamin D3 dihydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.22 vitamin D 1,25-hydroxylase

Specific Activity

Specific Activity on EC 1.14.15.22 - vitamin D 1,25-hydroxylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
wild-type, 1alpha-hydroxyvitamin D3 hydroxylation activity at C25 2.8 mmol of product per min and mol of protein, 25-hydroxyvitamin D3 hydroxylation activity at C1alpha 2.1 mmol of product per min and mol of protein