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Information on EC 1.14.15.22 - vitamin D 1,25-hydroxylase

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IUBMB Comments
A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase.
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Word Map
  • 1.14.15.22
  • 1alpha-hydroxylation
  • 1alpha,25-dihydroxyvitamin
  • sulfonylurea
  • 25-hydroxyvitamin
  • lividans
  • diterpenoids
  • bioconversion
  • 1alpha-hydroxyvitamin
  • abietic
  • schizosaccharomyces
  • 26-hydroxylation
  • herbicide-inducible
  • ferredoxins
  • pombe
  • synthesis
The expected taxonomic range for this enzyme is: Streptomyces griseolus
Reaction Schemes
+
+
2
reduced ferredoxin [iron-sulfur] cluster
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2
=
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2
oxidized ferredoxin [iron-sulfur] cluster
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+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
+
=
+
2
oxidized ferredoxin [iron-sulfur] cluster
+
Synonyms
cyp105a1, streptomyces griseolus cytochrome p450su-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(2)
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calciol + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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