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1.14.15.22: vitamin D 1,25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 1,25-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.22

Reaction

calcidiol
+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ +
O2
=
calcitriol
 + 2 oxidized ferredoxin [iron-sulfur] cluster +
H2O

Synonyms

CYP105A1, cytochrome P450SU-1, Streptomyces griseolus cytochrome P450SU-1, vitamin D3 dihydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.22 vitamin D 1,25-hydroxylase

Application

Application on EC 1.14.15.22 - vitamin D 1,25-hydroxylase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
expression of mutant R73V/R84A in Streptomyces lividans TK23 cells under the control of the tipA promoter leads to synthesis of 25-hydroxyvitamin D3 and large amounts of 1alpha,25-dihydroxyvitamin D3. In addition, polar metabolites 1alpha,25(R),26-trihydroxyvitamin D3 and 1alpha,25(R),26-trihydroxyvitamin D3 are observed at a ratio of 5:1