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1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase

This is an abbreviated version!
For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.57

Reaction

lithocholate
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
hyodeoxycholate
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.57 taurochenodeoxycholate 6alpha-hydroxylase

Reference

Reference on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Russell, D.W.
The enzymes, regulation, and genetics of bile acid synthesis
Annu. Rev. Biochem.
72
137-174
2003
Homo sapiens
Manually annotated by BRENDA team
Lundell, K.
The porcine taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21) gene: evolution by gene duplication and gene conversion
Biochem. J.
378
1053-1058
2004
Sus scrofa (Q9GJX5), Sus scrofa
Manually annotated by BRENDA team
Araya, Z.; Hellman, U.; Hansson, R.
Characterisation of taurochenodeoxycholic acid 6alpha-hydroxylase from pig liver microsomes
Eur. J. Biochem.
231
855-861
1995
Sus scrofa
Manually annotated by BRENDA team
Kramer, W.; Sauber, K.; Baringhaus, K.H.; Kurz, M.; Stengelin, S.; Lange, G.; Corsiero, D.; Girbig F.; König, W.; Weyland, C.
Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure
J. Biol. Chem.
276
7291-7301
2001
Oryctolagus cuniculus
Manually annotated by BRENDA team
Lundell, K.; Hansson, R.; Wikvall, K.
Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily
J. Biol. Chem.
276
9606-9612
2001
Sus scrofa (Q9GJX5), Sus scrofa
Manually annotated by BRENDA team
Araya, Z.; Wikvall, K.
6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
Biochim. Biophys. Acta
1438
47-54
1999
Homo sapiens
Manually annotated by BRENDA team
Lundell, K.; Wikvall, K.
Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)
Biochim. Biophys. Acta
1634
86-96
2003
Sus scrofa (Q9GJX5), Sus scrofa
Manually annotated by BRENDA team
Cheng, J.; Fang, Z.Z.; Kim, J.H.; Krausz, K.W.; Tanaka, N.; Chiang, J.Y.; Gonzalez, F.J.
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
J. Lipid Res.
55
455-465
2014
Mus musculus
Manually annotated by BRENDA team