1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase
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For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.57
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1.14.14.57
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bile
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porcine
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hyocholic
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hydroxylases
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developmental-dependent
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6alpha-hydroxylation
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cyp8b1
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fetal
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trihydroxy
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medicine
- 1.14.14.57
- bile
- porcine
-
hyocholic
- hydroxylases
-
developmental-dependent
-
6alpha-hydroxylation
- cyp8b1
- fetal
-
trihydroxy
- medicine
Reaction
Synonyms
CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase
ECTree
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Application on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase
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medicine
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vitamin D receptor deficiency in the intestine of mice exacerbates lithocholic acid-induced hepatotoxicity manifested by increased necrosis and inflammation, due in part to overaccumulation of hepatic bile acids including taurocholic acid and taurodeoxycholic acid. Intestinal expression of CYP3A4 in the Vitamin D receptor-deficient mouse line reduces lithocholic acid-induced hepatotoxicity through elevation of lithocholic acid metabolism and detoxification, and suppression of bile acid transporter expression in the small intestine