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1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase

This is an abbreviated version!
For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.57

Reaction

lithocholate
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
hyodeoxycholate
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.57 taurochenodeoxycholate 6alpha-hydroxylase

Application

Application on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
vitamin D receptor deficiency in the intestine of mice exacerbates lithocholic acid-induced hepatotoxicity manifested by increased necrosis and inflammation, due in part to overaccumulation of hepatic bile acids including taurocholic acid and taurodeoxycholic acid. Intestinal expression of CYP3A4 in the Vitamin D receptor-deficient mouse line reduces lithocholic acid-induced hepatotoxicity through elevation of lithocholic acid metabolism and detoxification, and suppression of bile acid transporter expression in the small intestine