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1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase

This is an abbreviated version!
For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.57

Reaction

lithocholate
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
hyodeoxycholate
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.57 taurochenodeoxycholate 6alpha-hydroxylase

Systematic Name

Systematic Name on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
taurochenodeoxycholate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5].