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1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase

This is an abbreviated version!
For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.57

Reaction

lithocholate
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
hyodeoxycholate
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.57 taurochenodeoxycholate 6alpha-hydroxylase

Substrates Products

Substrates Products on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
chenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
activity is low compared to activity with taurochenodeoxycholate
-
-
?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
-
?
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
additional information
?
-
-
isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid
-
-
?