1.14.14.57: taurochenodeoxycholate 6alpha-hydroxylase
This is an abbreviated version!
For detailed information about taurochenodeoxycholate 6alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.57
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1.14.14.57
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bile
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porcine
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hyocholic
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hydroxylases
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developmental-dependent
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6alpha-hydroxylation
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cyp8b1
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fetal
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trihydroxy
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medicine
- 1.14.14.57
- bile
- porcine
-
hyocholic
- hydroxylases
-
developmental-dependent
-
6alpha-hydroxylation
- cyp8b1
- fetal
-
trihydroxy
- medicine
Reaction
Synonyms
CYP3A4, CYP4A21, EC 1.14.13.97, taurochenodeoxycholate 6alpha-monooxygenase, taurochenodeoxycholic acid 6alpha-hydroxylase
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.57 - taurochenodeoxycholate 6alpha-hydroxylase
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REACTION DIAGRAM
chenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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activity is low compared to activity with taurochenodeoxycholate
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-
?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
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?
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
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isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid
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?
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
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?
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
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?