1.14.14.25: cholesterol 24-hydroxylase
This is an abbreviated version!
For detailed information about cholesterol 24-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.25
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1.14.14.25
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alzheimer
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24s-hydroxycholesterol
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oxysterols
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cyp27a1
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efavirenz
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24-hydroxylation
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medicine
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27-hydroxylase
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24s-ohc
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epsilon4
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lathosterol
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desmosterol
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cholesterol-metabolizing
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drug development
- 1.14.14.25
- alzheimer
- 24s-hydroxycholesterol
- oxysterols
- cyp27a1
- efavirenz
-
24-hydroxylation
- medicine
-
27-hydroxylase
-
24s-ohc
-
epsilon4
- lathosterol
- desmosterol
-
cholesterol-metabolizing
- drug development
Reaction
Synonyms
24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase, EC 1.14.13.98
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Source Tissue
Source Tissue on EC 1.14.14.25 - cholesterol 24-hydroxylase
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additional information
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in neurons and some astrocytes in the normal brain, in Alzheimer's disease the enzyme shows prominent expression in astrocytes and around amyloid plaques
predominantly expressed in. The 24-hydroxylase protein is first detected in the brain of mice at birth and continues to accumulate with age
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expression of Cyp46 in the brain is altered during normal development but is relatively stable in normal adult brain
quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview
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quantitative RT-PCR and real-time PCR CYP46 expression analysis, overview
neuronal-specific CYP46A1 protein levels are decreased in the putamen, but not cerebral cortex samples, of post-mortem Huntington's disease patients when compared to controls
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enzyme levels in healthy and injured brain, primary rat microglia, overview
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expression profile of Cyp46 in the brains of intact, sham-operated, and lesioned animals, overview. Ablation of the sensorimotor cortex induces increase of Cyp46 immunoreactivity in the ipsilateral cortex
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expression profile of Cyp46 in the brains of intact, sham-operated, and lesioned animals, overview. Ablation of the sensorimotor cortex induces increase of Cyp46 immunoreactivity in the ipsilateral cortex
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abnormal induction of the enzyme in patients with Alzheimers disease
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large pyramidal cells and their dendrites in cortical layers II, III, V, and VI. Is absent from nonpyramidal cells that compose layer IV
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specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body
quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview
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specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body
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contains cholesterol 24-hydroxylase mRNA but does not synthesize 24S-hydroxycholesterol
Cyp46A1 mRNA and CYP46A1 protein levels are decreased in the striatum of the R6/2 Huntington's disease mouse model and in SThdhQ111 cell lines
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Cyp46A1 mRNA and CYP46A1 protein levels are decreased in the striatum of the R6/2 Huntington's disease mouse model and in SThdhQ111 cell lines
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small amounts, mRNA does not appear to be translated into protein in the testis
additional information
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quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview
additional information
quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview
additional information
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immunohistochemic analysis of enzyme distribution, overview
additional information
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the enzyme is absent from a cortical section from a cholesterol 24-hydroxylase knockout mouse
additional information
R6/2 mice express exon 1 of the human mutant Huntingtons disease gene containing 160 CAG repeats, under control of the human HTT (IT15) promoter
additional information
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R6/2 mice express exon 1 of the human mutant Huntingtons disease gene containing 160 CAG repeats, under control of the human HTT (IT15) promoter
additional information
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R6/2 mice express exon 1 of the human mutant Huntingtons disease gene containing 160 CAG repeats, under control of the human HTT (IT15) promoter
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