Literature summary for 1.14.14.25 extracted from

Shafaati, M.; Mast, N.; Beck, O.; Nayef, R.; Heo, G.Y.; Bjoerkhem-Bergman, L.; Lutjohann, D.; Bjoerkhem, I.; Pikuleva, I.A.
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase (CYP46A1) in vitro and in vivo (2010), J. Lipid Res., 51, 318-323.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
voriconazole	binds with high affinity to CYP46A1 in vitro and efficiently inhibits CYP46A1-catalyzed cholesterol hydroxylations in the reconstituted system	Homo sapiens
voriconazole	voriconazole-induced visual disturbances related to an interaction between the drug and retinal CYP46A1	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
neural retina	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Mus musculus	(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Homo sapiens	(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
cholesterol 24S-hydroxylase	-	Mus musculus
cholesterol 24S-hydroxylase	-	Homo sapiens
CYP46A1	-	Mus musculus
CYP46A1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Mus musculus
NADPH	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000011	-	voriconazole	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	visual disturbances in CYP46A1 gene knockout mice	Mus musculus

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Release 2023.1 (January 2023)