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Literature summary for 1.14.14.25 extracted from

  • Cartagena, C.M.; Ahmed, F.; Burns, M.P.; Pajoohesh-Ganji, A.; Pak, D.T.; Faden, A.I.; Rebeck, G.W.
    Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain (2008), J. Neurotrauma, 25, 1087-1098.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information cortical injury increases cholesterol 24S hydroxylase levels in the rat brain, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Rattus norvegicus 24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme levels in healthy and injured brain, primary rat microglia, overview Rattus norvegicus
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hippocampus
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 Rattus norvegicus
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neuron primary hippocampal neurons Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
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 Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Synonyms

Synonyms Comment Organism
cholesterol 24S hydroxylase
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 Rattus norvegicus
CYP46
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
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 Rattus norvegicus