1.14.14.25: cholesterol 24-hydroxylase
This is an abbreviated version!
For detailed information about cholesterol 24-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.25
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1.14.14.25
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alzheimer
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24s-hydroxycholesterol
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oxysterols
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cyp27a1
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efavirenz
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24-hydroxylation
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medicine
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27-hydroxylase
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24s-ohc
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epsilon4
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lathosterol
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desmosterol
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cholesterol-metabolizing
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drug development
- 1.14.14.25
- alzheimer
- 24s-hydroxycholesterol
- oxysterols
- cyp27a1
- efavirenz
-
24-hydroxylation
- medicine
-
27-hydroxylase
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24s-ohc
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epsilon4
- lathosterol
- desmosterol
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cholesterol-metabolizing
- drug development
Reaction
Synonyms
24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase, EC 1.14.13.98
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Natural Substrates Products
Natural Substrates Products on EC 1.14.14.25 - cholesterol 24-hydroxylase
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REACTION DIAGRAM
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
(24S)-hydroxycholesterol + NADP+ + H2O
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the enzyme is important in cholesterol metabolism in the brain, overview
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview
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cholesterol + NADPH + O2
(24S)-hydroxycholesterol + NADP+ + H2O
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the enzyme is responsible for cholesterol elimination from brain, (24S)-hydroxycholesterol can cross the blood-brain barrier, enter the circulation, and then be delivered to the liver for further degradation, cholesterol metabolism, overview, CYP46A1 may participate in metabolism of neurosteroids and drugs that are targeted to the central nervous system
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cholesterol + NADPH + O2
(24S)-hydroxycholesterol + NADP+ + H2O
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the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview
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?
cholesterol + NADPH + O2
(24S)-hydroxycholesterol + NADP+ + H2O
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the enzyme is important in cholesterol metabolism in the brain, overview
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview
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24-hydroxycholesterol + oxidized adrenodoxin + H2O
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enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning
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cholesterol + reduced adrenodoxin + O2
24-hydroxycholesterol + oxidized adrenodoxin + H2O
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(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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r
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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initiates cholesterol degradation in the brain. In addition to the involvement in cholesterol homeostasis in the brain, this enzyme may participate in metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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a major pathway for excretion of excess cholesterol from the brain, polymorphisms within the CYP46A1 gene are associated with Alzheimers disease incidence. The ratio between 24S-OHC and 27-OHC is of importance for the generation of amyloid in the brain, overview
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain
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?
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview
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cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview
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?
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol + [reduced NADPH-hemoprotein reductase] + O2
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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CYP46A1 affects the pathophysiology of Alzheimers' disease and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease
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additional information
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regulation of cholesterol synthesis is more important for maintenance of cholesterol homeostasis in brain than is the corresponding regulation of cholesterol removal
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additional information
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the enzyme is a mediator of cholesterol homeostasis in the brain
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additional information
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the enzyme is a mediator of cholesterol homeostasis in the brain
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additional information
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(24S)-hydroxycholesterol is a potent activator of the LXR receptor, CYP46A1-deficiency plays a role in the pathogenesis of this neurological disorder, such as Alzheimer's disease
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additional information
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cholesterol metabolism is important in Alzheimer's disease pathogenesis, the enzyme is a risk factor for Alzheimer's disease, along with cholesterol 25-hydroxylase and ATP-binding cassette transporter A1, overview
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additional information
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the enzyme is a mediator of cholesterol homeostasis in the brain
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additional information
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the enzyme is a mediator of cholesterol homeostasis in the brain
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