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1.11.2.2: myeloperoxidase

This is an abbreviated version!
For detailed information about myeloperoxidase, go to the full flat file.

Word Map on EC 1.11.2.2

Reaction

Cl-
+
H2O2
 +
H+
=
HClO
 +
H2O

Synonyms

donor, hydrogen peroxide oxidoreductase, donor, hydrogen peroxideoxidoreductase, donor: H2O2 oxidoreductase, donor:H2O2 oxidoreductase, donor:hydrogen peroxide oxidoreductase, donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7, epx2a, hemi-MPO, hemi-myeloperoxidase, LPO, MPO, MPX, myeloperoxidase, peroxinectin, properoxinectin, recombinant human MPO, rhMPO, tissue myeloperoxidase

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.2 myeloperoxidase

Activating Compound

Activating Compound on EC 1.11.2.2 - myeloperoxidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-aminosalicylic acid
-
converts inactive myeloperoxidase compound II rapidly into active myeloperoxidase
ascorbic acid
betanin
-
low micromolar betanin concentrations enhance the chlorination activity of MPO at pH 7.0, increasing the betanin concentration up to 0.006 mM dramatically increases the chlorination rate of monochlorodimedon
chloride
-
in the presence of 100 mM NaCl the catalytic efficiency of MPO increases 3-4fold whatever the sulfide considered, the rate of 4-tolyl methyl sulphide oxidation enhancement is about 8fold at 120 mM NaCl
D-penicillamine
-
addition of D-penicillamine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (17.2% increase at 5 mM)
ferrocyanide
-
converts inactive myeloperoxidase compound II into active myeloperoxidase
glutathione
-
addition of glutathione significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (24% increase at 5 mM)
indicaxanthin
-
at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO
L-cysteine
-
addition of L-cysteine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (45.4% increase at 5 mM)
myelin oligodendrocyte protein
-
MPO activity increases significantly in the myelin oligodendrocyte protein treated rats (0.05 mg)
-
N-acetyl-L-cysteine
-
addition of N-acetyl-L-cysteine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (16.3% increase at 5 mM)
NaCl
-
maximal activity in the presence of 200 mM NaCl
serotonin
at low micromolar concentrations (below 0.02 mM), serotonin enhances hypochlorite production by both purified myeloperoxidase and neutrophils
additional information
-
hypercholesterolemia results in higher tissue MPO activities, the influences of fish oil on MPO activities are not obvious in hypercholesterolemic mice with sepsis
-