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1.11.2.2: myeloperoxidase

This is an abbreviated version!
For detailed information about myeloperoxidase, go to the full flat file.

Word Map on EC 1.11.2.2

Reaction

Cl-
+
H2O2
 +
H+
=
HClO
 +
H2O

Synonyms

donor, hydrogen peroxide oxidoreductase, donor, hydrogen peroxideoxidoreductase, donor: H2O2 oxidoreductase, donor:H2O2 oxidoreductase, donor:hydrogen peroxide oxidoreductase, donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7, epx2a, hemi-MPO, hemi-myeloperoxidase, LPO, MPO, MPX, myeloperoxidase, peroxinectin, properoxinectin, recombinant human MPO, rhMPO, tissue myeloperoxidase

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.2 myeloperoxidase

Inhibitors

Inhibitors on EC 1.11.2.2 - myeloperoxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2Z)-1-(2-aminophenyl)-3-phenylprop-2-en-1-one
-
-
(2Z)-1-(3-aminophenyl)-3-phenylprop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(furan-2-yl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(naphthalen-1-yl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one
-
-
(2Z)-1-(4-aminophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
-
-
(5-(((5-amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl)oxy)methyl)-2-phenyl-2H-1,2,3-triazol-4-yl)methanol
-
-
(E)-(2,4-dihydroxy)-alpha-aminocinnamic acid
-
-
(E)-(2,5-dihydroxy)-alpha-aminocinnamic acid
-
-
(E)-(2-hydroxy)-alpha-aminocinnamic acid
-
-
(E)-(2-hydroxy-5-methoxy)-alpha-aminocinnamic acid
-
-
(E)-(2-hydroxy-5-nitro)-alpha-aminocinnamic acid
-
-
(E)-(3-ethoxy-2-hydroxy)-alpha-aminocinnamic acid
-
-
(E)-(5-amino-2-hydroxy)-alpha-aminocinnamic acid
-
-
(E)-(5-bromo-2-hydroxy)-alpha-aminocinnamic acid
-
-
(E)-(5-chloro-2-hydroxy)-alpha-aminocinnamic acid
-
-
(E)-2-hydroxycinnamic acid
-
-
(E)-dehydro-phenylalanine
-
-
(R)-7-(1,2-diphenylethyl)-1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(1,4-diphenylbutyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(1-phenyl-3-((2-(trifluoromethyl)benzyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(1-phenyl-3-((4-phenylbicyclo[2.2.2]octan-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine trifluoroacetate salt
-
-
(R)-7-(1-phenyl-3-((pyridin-2-ylmethyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(1-phenyl-4-(4-phenylpiperidin-1-yl)butyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(3-((2-fluoroethyl)(4-phenylbicyclo[2.2.2]octan-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(3-(benzylamino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(3-(benzyloxy)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(R)-7-(3-(methyl(4-phenylbicyclo[2.2.2]octan-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
(Z)-2-hydroxycinnamic acid
-
-
(Z)-dehydro-phenylalanine
-
-
1,4-bis[(2-fluorophenyl)methyl]piperazine
-
1,4-bis[(3-fluorophenyl)methyl]piperazine
-
1,4-bis[(4-fluorophenyl)methyl]piperazine
-
1,4-dibenzylpiperazine
-
1-(2-[(propan-2-yl)oxy]ethyl)-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. AZD-3241, irreversible inhibitor
-
2,2'-[piperazine-1,4-diylbis(methylene)]diphenol
-
2-(2-[[(3-fluorophenyl)methyl]amino]ethyl)phenol
-
2-(2-[[(4-fluorophenyl)methyl]amino]ethyl)phenol
-
2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyrimidine-5-carbohydroxamic acid
2-(3-[[(2-fluorophenyl)methyl]amino]propyl)phenol
-
2-(3-[[(2-hydroxyphenyl)methyl]amino]propyl)phenol
-
2-(3-[[(3-fluorophenyl)methyl]amino]propyl)phenol
-
2-(3-[[(4-fluorophenyl)methyl]amino]propyl)phenol
-
2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
PF-1355
-
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
PF-06282999
-
2-([[2-(2-fluorophenyl)ethyl]amino]methyl)phenol
-
2-([[2-(2-hydroxyphenyl)ethyl]amino]methyl)phenol
-
2-([[2-(2-methoxyphenyl)ethyl]amino]methyl)phenol
-
2-([[2-(5-fluoro-1H-indol-3-yl)ethyl]amino]methyl)phenol
-
2-([[3-(2-fluorophenyl)propyl]amino]methyl)phenol
-
2-([[3-(2-methoxyphenyl)propyl]amino]methyl)phenol
-
2-([[3-(5-fluoro-1H-indol-3-yl)propyl]amino]methyl)phenol
-
2-aminobenzoic acid hydrazide
-
2-[(piperidin-1-yl)methyl]phenol
-
2-[(piperidin-3-yl)methyl]phenol
-
2-[2-(benzylamino)ethyl]phenol
-
2-[3-(benzylamino)propyl]phenol
-
2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl]acetamide
-
2-[[(2-phenylethyl)amino]methyl]phenol
-
2-[[(3-phenylpropyl)amino]methyl]phenol
-
2-[[3,5-bis(trifluoromethyl)benzyl]amino]-N,4-dihydroxypyrimidine-5-carboxamide
-
-
3-((5-amino-3H-[1,2,3]triazolo[4,5-b] pyridin-7-yl)methyl)benzonitrile
-
-
3-(dimethylamino) benzoic acid hydrazide
-
3-([(2R)-oxolan-2-yl]methyl)-2-sulfanylidene-1,2,3,7-tetrahydro-6H-purin-6-one
i.e. TX4, irreversible inhibitor
-
3-isobutyl-2-thioxo-7H-purin-6-one
TX1
-
3-methoxybenzoic acid hydrazide
-
-
3-nitrobenzoic acid hydrazide
-
-
3-[(4-fluorophenyl)methyl]-2-sulfanylidene-1,2,3,7-tetrahydro-6H-purin-6-one
-
i.e. TX2, irreversible inhibitor
-
4'-amino-4-fluorochalcone
-
potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM
4'-amino-4-methylchalcone
-
potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM
4'-aminochalcone
-
potent inhibition of the chlorinating activity. Compound is not toxic to neutrophils at concentrations below 100 microM
4-(5-fluoro-1H-indol-3-yl)butanamide
reversible myeloperoxidase inhibitor, efficiently prevents enzyme-dependent LDL oxidation
4-(7-fluoro-1H-indol-3-yl)butanamide
-
4-(trifluoromethyl) benzoic acid hydrazide
4-amino benzoic acid hydrazide
-
4-aminobenzohydrazide
-
4-aminobenzoic acid hydrazide
4-aminobenzoic acid hydrazine
-
metabolism of chloroacetonitrile to cyanide by MPO/H2O2/Cl- system is significantly reduced by 4-amino benzoic acid hydrazine to 52.6% of control value
4-chlorobenzoic acid hydrazide
-
-
4-fluorobenzoic acid hydrazide
-
4-hydroxy-2,2,6,6-tetra-methyl-1-piperidinyloxy radical
-
tempol, 0.01 mM tempol efficiently inhibits peroxidase-mediated RNase nitration
4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl
i.e. tempol, inhibits both H2O2 consumption and taurine chlorination, reacts mostly as a reversible inhibitor of MPO by trapping it as MPO-II and the MPO-II-tempol complex, which are not within the chlorinating cycle
4-hydroxybenzoic acid hydrazide
-
-
4-methoxybenzoic acid hydrazide
-
-
4-nitrobenzoic acid hydrazide
-
4-[(1Z)-3-(4-aminophenyl)-3-oxoprop-1-en-1-yl]benzonitrile
-
-
5-(7-fluoro-1H-indol-3-yl)pentanamide
-
5-aminosalicylic acid
-
5-chlorotryptamine
-
IC50: 0.00073 mM
5-fluorotryptamine
5-thio-2-nitrobenzoic acid
-
competitive inhibitor of myeloperoxidase
7-(((5-(difluoromethyl)-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)thio)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2'-fluorobiphenyl-3-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2,6-dichlorobenzyl)oxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2,6-dichlorobenzyl)thio)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2-(1H-pyrazol-1-yl)benzyl)oxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2-(methylsulfonyl)benzyl)oxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((2-fluorobenzyl)thio)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((3'-fluoro-2-methylbiphenyl-3-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((3'-fluorobiphenyl-3-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((3-phenylisoxazol-5-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((4-chloro-3'-fluorobiphenyl-3-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((5-(difluoromethyl)-2-phenyl-2H-1,2,3-triazol-4-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methoxy)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-((5-phenyloxazol-2-yl)methoxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-1-phenyl-3-(((1R,3R)-3-phenylcyclopentyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-1-phenyl-3-(((1R,4S)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-1-phenyl-3-(((1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-1-phenyl-3-(((3R,6S)-6-phenyltetrahydro-2H-pyran-3-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-1-phenyl-3-((trans-4-phenylcyclohexyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-((R)-3-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(1,4-diphenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(1-phenyl-3-((1-phenyl-2-oxabicyclo[2.2.2]octan-4-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(2-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-(2-chlorobenzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(2-fluorobenzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(2-fluorobenzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(2-methyl-3-(1-methyl-1H-pyrazol-3-yl)benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(3-(1-methyl-1H-pyrazol-3-yl)benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(3-(1-methyl-1H-pyrazol-4-yl)benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(3-(trifluoromethyl)benzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(3-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-(3-chlorobenzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(3-methoxycarbonylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-(3-phenylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-(4-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine
-
-
7-(4-chlorobenzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(5-amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl)-13-(2-phenylethyl)-3,4,10,13-tetraazatricyclo[13.3.1.13,6]icosa-1(19),4,6(20),15,17-pentaen-12-one
-
-
-
7-(benzyloxy)-3a,7a-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
-
-
7-(benzyloxy)-3H-[1,2,3]triazolol[4,5-d]pyrimidin-5-amine
-
-
7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
-
-
-
7-(naphthalen-2-ylmethyl)-3H-[1,2,3] triazolo[4,5-b]pyridin-5-amine
-
-
7-([1-[(3-benzylphenyl)methyl]-1H-pyrazol-3-yl]methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-([1-[(3-phenoxyphenyl)methyl]-1H-pyrazol-3-yl]methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-([1-[(3-[[(3S)-pyrrolidin-3-yl]oxy]phenyl)methyl]-1H-pyrazol-3-yl]methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
7-[(1-benzyl-1H-pyrazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(1-phenyl-1H-pyrazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(1-[[3-(piperidin-4-yl)phenyl]methyl]-1H-pyrazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(17S)-18-phenyl-16-oxa-2,8,9-triazapentacyclo[16.2.2.11,17.16,9.111,15]pentacosa-6(25),7,11(24),12,14-pentaen-5-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(1R)-1-phenyl-3-[(4-phenylbicyclo[2.2.2]octan-1-yl)amino]propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(1R)-3-[[(1R)-2,3-dihydro-1H-inden-1-yl]amino]-1-phenylpropyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(2-fluorobenzyl)sulfanyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[(3R,4S,6S)-4-benzyl-2-oxa-7,13,14-triazatetracyclo[14.3.1.13,6.111,14]docosa-1(20),11(21),12,16,18-pentaen-10-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[14'-oxa-3',4',10'-triazaspiro[cyclopentane-1,12'-tricyclo[13.3.1.13,6]icosane]-1'(19'),4',6'(20'),15',17'-pentaen-7'-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[17-oxa-3,4,10-triazatetracyclo[16.3.1.13,6.112,16]tetracosa-1(22),4,6(24),12(23),13,15,18,20-octaen-7-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[17-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12(24),13,15,19,21-octaen-7-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12(24),13,15,19,21-octaen-7-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13(24),14,16,19,21-octaen-7-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[18-oxa-3,4,10-triazatetracyclo[18.3.1.13,6.113,17]hexacosa-1(24),4,6(26),13(25),14,16,20,22-octaen-7-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[3-oxa-10,11,17-triazatetracyclo[16.2.2.14,8.110,13]tetracosa-4(24),5,7,11,13(23)-pentaen-14-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetracosa-1(22),2(24),3,5,9,11(23),18,20-octaen-12-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(1,2,3,4-tetrahydroisoquinolin-6-ylmethyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(4-fluorophenyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(biphenyl-3-yl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(biphenyl-3-ylmethyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(isoquinolin-6-ylmethyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(naphthalen-2-ylmethyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-(pyridin-2-yl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
7-[[1-([3-[(2,3-dihydro-1H-isoindol-4-yl)oxy]phenyl]methyl)-1H-pyrazol-3-yl]methyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
-
-
-
8-[(2-aminoethyl)amino]-3,7-dihydro-3-methyl-7-(3-phenoxypropyl)-1H-purine-2,6-dione
-
acetaminophen
-
Aminotriazole
-
3 mM inhibitory
benzoic acid hydrazide
benzoic hydrazide
-
-
betanin
-
higher micromolar betanin concentrations inhibit the MPO-mediated chlorination reactions by scavenging of hypochlorous acid
bis-2,2'-[(dihydro-1,3(2H,4H) pyrimidinediyl)bis(-methylene)]phenol
-
catalase
-
ceruloplasmin
-
cyanine-5-hydrazide
-
-
dapsone
dityrosine
inhibits MPO-derived dityrosine formation in a dose-dependent manner
ferulic acid
-
HClO
-
-
indicaxanthin
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at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO, whereas at pH 5.0 only inhibitory effects are observed even at micromolar concentrations
indomethacin
kaempferol
kaempferol-7-O-rhamnoside
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8% inhibition at 0.1 mM for 10 min
leptosperin
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methionine
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myricetin
Myricitrin
N-acetyl-L-Lys-L-Tyr-L-Cys-amide
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N-benzyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
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N-[(2-fluorophenyl)methyl]-3-(2-methoxyphenyl)propan-1-amine
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NAc-L-Lys-L-Tyr-L-Cys-NH2
-
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nitrite
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nitrite is an excellent inhibitor of the chlorination activity of myeloperoxidase, there is progressive inhibition of enzyme activity with increasing concentration of nitrite up to a maximum of 80%. Upon addition of 100 mM L-tyrosine, enzyme activity is completely restored
o-Dianisidine
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higher concentrations than 1.54 mM inhibitory
paracetamol
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peptide inhibitor of complement C1
11.5fold reduction in enzyme activity at 7.5 mM
-
Q3GA
inhibits MPO-derived dityrosine formation in a dose-dependent manner
quercetin
RPYLKVNPR
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Salicylhydroxamic acid
serotonin
at higher concentrations than 0.02 mM, serotonin almost completely blocks the formation of hypochlorite
Sodium azide
SPIN protein
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-
staphyloxanthin
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Sulfide
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at high sulfide concentrations, enzymic inhibition is observed above 0.25 mM (20% inhibition at 0.3 mM sulfide)
taxifolin
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tryptamine
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Urate
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additional information
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