1.11.2.2: myeloperoxidase

This is an abbreviated version!
For detailed information about myeloperoxidase, go to the full flat file.

Word Map on EC 1.11.2.2

Reaction

Cl-
+
H2O2
+
H+
=
HClO
+
H2O

Synonyms

donor, hydrogen peroxide oxidoreductase, donor, hydrogen peroxideoxidoreductase, donor: H202 oxidoreductase, donor: H2O2 oxidoreductase, donor:H2O2 oxidoreductase, donor:hydrogen peroxide oxidoreductase, donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7, hemi-MPO, hemi-myeloperoxidase, LPO, MPO, myeloperoxidase, peroxinectin, properoxinectin, recombinant human MPO, rhMPO, tissue myeloperoxidase

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.2 myeloperoxidase

Natural Substrates Products

Natural Substrates Products on EC 1.11.2.2 - myeloperoxidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ascorbate + H2O2
?
show the reaction diagram
-
-
-
-
?
Br- + H2O2
?
show the reaction diagram
-
-
-
-
?
Br- + H2O2 + H+
HBrO + H2O
show the reaction diagram
-
-
-
-
?
Cl- + H2O2
HClO + H2O
show the reaction diagram
Cl- + H2O2 + H+
HClO + H2O
show the reaction diagram
Cl- + H2O2 + H+ + taurine + H+
taurine monochloroamine + 2 H2O
show the reaction diagram
-
the taurine chlorination reaction mediated by the myeloperoxidase system in vivo may involve an enzyme intermediate species rather than free HOCl
-
-
?
donor + H2O2
oxidized donor + H2O
show the reaction diagram
-
involved in immune defense reactions
-
-
r
donor + HOCl
oxidized donor + Cl-
show the reaction diagram
-
involved in immune defense reactions
-
-
r
I- + H2O2
?
show the reaction diagram
L-tyrosine + H2O2 + H+
dityrosine + H2O
show the reaction diagram
-
-
-
-
?
monochlorodimedon + Cl-
dichlorodimedon
show the reaction diagram
-
-
-
-
?
nitric oxide + H2O2
?
show the reaction diagram
-
-
-
-
?
nitrite + H2O2
?
show the reaction diagram
-
-
-
-
?
serotonin + H2O2 + H+
tryptamine dione + H2O
show the reaction diagram
-
-
-
-
?
thiocyanate + H2O2
hypothiocyanite + H2O
show the reaction diagram
-
-
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanite + H2O
show the reaction diagram
-
thiocyanate is a major physiological substrate of myeloperoxidase and most favoured substrate compared to chloride and bromide
-
-
?
thiocyanate + H2O2 + H+
hypothiocyanous acid + H2O
show the reaction diagram
-
-
-
-
?
tyrosine + H2O2
?
show the reaction diagram
-
-
-
-
?
urate + H2O2
5-hydroxyisourate + H2O
show the reaction diagram
-
-
-
-
?
urate + H2O2 + H+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-