2.7.7.24: glucose-1-phosphate thymidylyltransferase

This is an abbreviated version!
For detailed information about glucose-1-phosphate thymidylyltransferase, go to the full flat file.

Reaction

Synonyms

Cps23FL, Cps2L, D-glucose-1-phosphate thymidylyltransferase, DnmL, dTDP-alpha-D-glucose pyrophosphorylase, dTDP-D-glucose synthase, dTDP-glucose synthase, dTDP-glucose-pyrophosphorylase, dTDPglucose pyrophosphorylase, Glc-1-P thymidylyltransferase, Glc-1-P TTase, Glc-1-P-TT, Glc1P-thymidylyltransferase, glucose 1-phosphate thymidylyltransferase, glucose-1-phosphate thymidylyltransferase, RfbA, rml-1, RmlA, RmlA protein, SchS6, SgcA1, ST0452, sugar-1-phosphate nucleotidyltransferase, TDP-glucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidylyltransferase, glucose 1-phosphate, ugpG, UgpG protein, UTP/dTTP-glucose-1-phosphate uridylyl/thymidylyl transferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.24 glucose-1-phosphate thymidylyltransferase

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Results	in table
35934	AA Sequence
4	Application
1	CAS Registry Number
28	Cloned(Commentary)
7	Crystallization (Commentary)
11	General Information
3	IC50 Value
17	Inhibitors
16	kcat/KM [mM/s]
3	Ki Value [mM]
77	KM Value [mM]
40	Metals/Ions
11	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
101	Organism
30	Pathway
188	PDB ID
13	pH Optimum
4	pH Range
42	Protein Variants
29	Purification (Commentary)
2	Reaction
1	Reaction Type
56	Reference
3	Source Tissue
14	Specific Activity [micromol/min/mg]
4	Storage Stability
149	Substrates and Products (Substrate)
14	Subunits
73	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Range [°C]
6	Temperature Stability [°C]
57	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.7.7.24 - glucose-1-phosphate thymidylyltransferase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with dTDP-alpha-D-glucose and diphosphate, sitting drop vapor diffusion method, using 0.2 M sodium sulfate, 0.1 M bis-Tris propane pH 8.5, 20% (w/v) PEG 3350

Bacillus anthracis

A0A4Y1W0P1

760291

co-crystallization with dTDP-glucose or dTMP and alpha-D-glucose 1-phosphate or deoxythymidine and alpha-D-glucose 1-phosphate, hanging-drop vapour-diffusion method in 1.7 M ammonium sulfate and 0.1 M sodium acetate, pH 5.3

Escherichia coli

-

643081

enzyme in complex with either dTTP or dTDP-alpha-D-glucose, hanging drop vapor diffusion method, using either 18-22% (w/v) poly(ethylene glycol) 8000 and 100 mM MOPS (pH 7.0) or 20% (w/v) poly(ethylene glycol) 3350, 200 mM KCl and 100 mM CHES (pH 9.0), respectively

Mycobacterium tuberculosis

P9WH13

762339

sitting-drop vapour-diffusion method in polyethylene glycol 6000, 0.1 M sodium citrate, pH 4.6 and 0.5 M Li2SO4 as precipitant, crystallization as apoenzyme or co-crystallization with dTTP or thymidine and alpha-D-glucose 1-phosphate or dTDP-D-glucose or dTDP-L-rhamnose

Pseudomonas aeruginosa

-

643084

sitting-drop vapour-diffusion method in polyethylene glycol 6000, 0.1 M sodium citrate, pH 4.6 and 0.5 M Li2SO4 as precipitant, space group: P1, the asymmetric unit contains eight monomers in the form of two RmlA tetramers with a solvent content of 51%

Pseudomonas aeruginosa

-

643083

sitting-drop vapour-diffusion technique with PEG 6000 and lithium sulfate as precipitant. Several diffraction data sets of single frozen crystals are collected to a resolution of 1.66 A. Crystals belong to space group P1, with unit-cell parameters a = 71.5 A, b = 73.1 A, c = 134.7 A, alpha = 89.9°, beta = 80.9°, gamma = 81°

Pseudomonas aeruginosa

-

643083

homology modeling of both isoforms DnmL and RmbA

Streptomyces peucetius

C6K8M0

723689