2.7.1.158: inositol-pentakisphosphate 2-kinase

This is an abbreviated version!
For detailed information about inositol-pentakisphosphate 2-kinase, go to the full flat file.

Reaction

Synonyms

ASP1, At5g42810, AtIP5 2-K, AtIPK1, CnIpk1, Glyma04g03240, Glyma06g03310, GmIpk1, GmlPk1, Gsl1p, inositol 1,3,4,5,6-pentakis phosphate 2-kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, inositol hexakisphosphate kinase 1, inositol kinase, inositol pentakisphosphate 2-kinase, inositol polyphosphate kinase, inositol polyphosphate kinase-1, inositol polyphosphate kinase/phosphotransferase, inositol-1,3,4,5,6-pentakisphosphate 2-kinase, ins(1,3,4,5,6)P5 2-kinase, Ins5 2-kinase, InsP5 2-kinase, InsP6-kinase, IP5 2-K, IP5 2-kinase, IP5K, IP6K, IP6K1, Ipk1, Ipk1p, IPP2K, mIP5 2-K, Plc1p, rIPK1, scIpk1, spIpk1-C, StITPK1, StITPKalpha, ZmIPK1, ZmIPK1A, ZmIPK1B

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.158 inositol-pentakisphosphate 2-kinase

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Results	in table
3	Activating Compound
3687	AA Sequence
1	Application
1	CAS Registry Number
22	Cloned(Commentary)
11	Cofactor
4	Crystallization (Commentary)
31	Disease/ Diagnostics
32	General Information
2	General Stability
1	IC50 Value
11	Inhibitors
4	kcat/KM [mM/s]
33	KM Value [mM]
20	Localization
14	Metals/Ions
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
43	Organism
8	Pathway
37	PDB ID
8	pH Optimum
1	pH Range
2	pI Value
27	Protein Variants
15	Purification (Commentary)
1	Reaction
3	Reaction Type
39	Reference
70	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
65	Substrates and Products (Substrate)
16	Subunits
108	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Turnover Number [1/s]

Disease

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Disease on EC 2.7.1.158 - inositol-pentakisphosphate 2-kinase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Autoimmune Diseases

Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.

26121493

Dehydration

Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective.

33247842

Diabetes Mellitus, Type 1

Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria.

19643930

Diabetes Mellitus, Type 1

Urine Inositol Pentakisphosphate 2-kinase and Changes in Kidney Structure in Early Diabetic Kidney Disease in Type 1 Diabetes.

30132343

Diabetic Nephropathies

Urine Inositol Pentakisphosphate 2-kinase and Changes in Kidney Structure in Early Diabetic Kidney Disease in Type 1 Diabetes.

30132343

Graft vs Host Disease

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.

31697815

Herpes Zoster

Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria.

19643930

Infections

A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens.

18643983

Melanoma

Melanocyte-stimulating hormone (alpha-MSH) inhibits the growth of human malignant melanoma cells with the induction of phosphatidyl inositol and myo-inositol phosphate levels.

1665968

Neoplasms

Phosphoinositide phosphorylation precedes growth in rat mammary tumors.

3004470

Neoplasms

The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats.

29043842

Neoplasms

Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria.

19643930

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