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2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol-4-phosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.154

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 4-phosphate
=
ADP
+
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

Synonyms

C2-domain-containing phosphoinositide 3-kinase, C2-PI3K, class I phosphoinositide 3-kinase, class II phosphoinositide 3 kinase alpha subunit, class II phosphoinositide 3-kinase, class II phosphoinositide 3-kinase alpha, class II phosphoinositide 3-kinase alpha-isoform, class II phosphoinositide 3-kinase C2alpha, class II phosphoinositide 3-kinase C2beta, class II phosphoinositide 3-kinases PI3K-C2alpha, class II PI3K, class II PI3K-C2alpha, class III phosphoinositide 3-kinase, class-I PI 3-kinase, class-II PI 3-kinase, HsC3-PI3K, kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-, p170, phosphatidylinositol 3-kinase class 2 beta, phosphatidylinositol 3-kinase class II alpha, phosphoinositide 3-kinase, phosphoinositide 3-kinase C2 beta, phosphoinositide 3-kinase C2beta, phosphoinositide 3-kinase-C2-beta, phosphoinositide 3-kinase-C2-gamma, phosphoinositide 3-kinases, PI 3-kinase, PI 3-kinase C2alpha, PI 3-kinase C2beta, PI 3-kinase C2gamma, PI3K, PI3K-C2alpha, PI3K-C2beta, PI3K-C2gamma, PI3KC2a, PI3KC2alpha, PI3KC2b, PI3KC2beta, PI3KC2gamma, PI3K_68D, PI3K_C2alpha, PI3K_C2gamma, PIK3C2G, PtdIns-3-kinase C2alpha, PtdIns-3-kinase C2beta, PtdIns-3-kinase C2gamma, type II phosphoinositide 3-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase

Activating Compound

Activating Compound on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
A23187
-
Ca2+-ionophore, activates enzyme form PI3K-C2beta, mimicks hepatocyte growth factor HGF
growth factors
addition of serum to growth-factor-deficient medium increases PI3K-C2alpha expression
-
hepatocyte growth factor HGF
-
in renal brush-border and basal lateral plasma membranes, in the latter case mediated by calpain
-
Insulin
-
ITSN1
-
leptin
-
4fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, no recruitment of tyrosine phosphorylated proteins to the isozyme, blockade of activation by MEK-inhibitor PD98059
-
lysophosphatidic acid
monocyte chemotactic peptide-1
-
agonist-induced activation
-
TNF-alpha
-
2.8fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, blockade of activation by MEK-inhibitor PD98059
-
additional information
-