2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase

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For detailed information about phosphatidylinositol-4-phosphate 3-kinase, go to the full flat file.

Reaction

Synonyms

C2-domain-containing phosphoinositide 3-kinase, C2-PI3K, class I phosphoinositide 3-kinase, class II phosphoinositide 3 kinase alpha subunit, class II phosphoinositide 3-kinase, class II phosphoinositide 3-kinase alpha, class II phosphoinositide 3-kinase alpha-isoform, class II phosphoinositide 3-kinase C2alpha, class II phosphoinositide 3-kinase C2beta, class II phosphoinositide 3-kinases PI3K-C2alpha, class II PI3K, class II PI3K-C2alpha, class III phosphoinositide 3-kinase, class-I PI 3-kinase, class-II PI 3-kinase, HsC3-PI3K, kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-, p170, phosphatidylinositol 3-kinase class 2 beta, phosphatidylinositol 3-kinase class II alpha, phosphoinositide 3-kinase, phosphoinositide 3-kinase C2 beta, phosphoinositide 3-kinase C2beta, phosphoinositide 3-kinase-C2-beta, phosphoinositide 3-kinase-C2-gamma, phosphoinositide 3-kinases, PI 3-kinase, PI 3-kinase C2alpha, PI 3-kinase C2beta, PI 3-kinase C2gamma, PI3K, PI3K-C2alpha, PI3K-C2beta, PI3K-C2gamma, PI3KC2a, PI3KC2alpha, PI3KC2b, PI3KC2beta, PI3KC2gamma, PI3K_68D, PI3K_C2alpha, PI3K_C2gamma, PIK3C2G, PtdIns-3-kinase C2alpha, PtdIns-3-kinase C2beta, PtdIns-3-kinase C2gamma, type II phosphoinositide 3-kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase

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Results	in table
15	Activating Compound
132	AA Sequence
2	Application
2	CAS Registry Number
20	Cloned(Commentary)
9	Cofactor
409	Disease/ Diagnostics
4	Expression
34	General Information
6	IC50 Value
82	Inhibitors
8	KM Value [mM]
26	Localization
15	Metals/Ions
10	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
3	Pathway
34	PDB ID
5	Posttranslational Modification
11	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
135	Source Tissue
1	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
20	Subunits
104	Synonyms
1	Systematic Name

Expression

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Expression on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

insulin incubation also significantly upregulates the mRNA expression of PI3KCb and PI3KC2a

Tachysurus fulvidraco

A0A2I4KAQ4, A0A2I4KAQ7

761194

PI3KC2alpha mRNA is downregulated in islets from type 2 diabetic patients compared to nondiabetic individuals

Homo sapiens

O00443, O00750, O75747

761670

PI3KCb and PI3KC2a mRNA levels are significantly lower in insulin/wortmannin group than those in single insulin group. Single wortmannin treatment shows no differences on the mRNA level of all PI3Ks, but wortmannin pretreatment significantly reduces insulin-induced upregulation on the mRNA level of PI3KCb and PI3KC2a

Tachysurus fulvidraco

A0A2I4KAQ4, A0A2I4KAQ7

761194

PI3KCb and PI3KC2a mRNA levels are significantly lower in insulin/wortmannin group than those in single insulin group. Single wortmannin treatment shows no differences on the mRNA level of all PI3Ks, but wortmannin pretreatment significantly reduces insulin-induced upregulation on the mRNA level of PI3KCb and PI3KC2a in insulin/wortmannin group than those in single insulin group

Tachysurus fulvidraco

A0A2I4KAQ4, A0A2I4KAQ7

761194