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2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol-4-phosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.154

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 4-phosphate
=
ADP
+
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

Synonyms

C2-domain-containing phosphoinositide 3-kinase, C2-PI3K, class I phosphoinositide 3-kinase, class II phosphoinositide 3 kinase alpha subunit, class II phosphoinositide 3-kinase, class II phosphoinositide 3-kinase alpha, class II phosphoinositide 3-kinase alpha-isoform, class II phosphoinositide 3-kinase C2alpha, class II phosphoinositide 3-kinase C2beta, class II phosphoinositide 3-kinases PI3K-C2alpha, class II PI3K, class II PI3K-C2alpha, class III phosphoinositide 3-kinase, class-I PI 3-kinase, class-II PI 3-kinase, HsC3-PI3K, kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-, p170, phosphatidylinositol 3-kinase class 2 beta, phosphatidylinositol 3-kinase class II alpha, phosphoinositide 3-kinase, phosphoinositide 3-kinase C2 beta, phosphoinositide 3-kinase C2beta, phosphoinositide 3-kinase-C2-beta, phosphoinositide 3-kinase-C2-gamma, phosphoinositide 3-kinases, PI 3-kinase, PI 3-kinase C2alpha, PI 3-kinase C2beta, PI 3-kinase C2gamma, PI3K, PI3K-C2alpha, PI3K-C2beta, PI3K-C2gamma, PI3KC2a, PI3KC2alpha, PI3KC2b, PI3KC2beta, PI3KC2gamma, PI3K_68D, PI3K_C2alpha, PI3K_C2gamma, PIK3C2G, PtdIns-3-kinase C2alpha, PtdIns-3-kinase C2beta, PtdIns-3-kinase C2gamma, type II phosphoinositide 3-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase

Reference

Reference on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Mol. Cell. Biol.
20
3817-3830
2000
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.
Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity
J. Biol. Chem.
273
33082-33090
1998
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Biochem. J.
326
139-147
1997
Homo sapiens, Homo sapiens PI3K-C2alpha
-
Manually annotated by BRENDA team
Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.
CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain
J. Biol. Chem.
271
13892-13899
1996
Mus musculus (Q61194), Drosophila melanogaster (Q7JNX6)
Manually annotated by BRENDA team
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Homo sapiens, Mus musculus, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K
Biochem. Biophys. Res. Commun.
233
537-544
1997
Homo sapiens (O00750)
Manually annotated by BRENDA team
Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
Biochem. Biophys. Res. Commun.
244
531-539
1998
Mus musculus (O70167), Mus musculus
Manually annotated by BRENDA team
Ono, F.; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.
A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration
J. Biol. Chem.
273
7731-7736
1998
Rattus norvegicus (O70173)
Manually annotated by BRENDA team
Rozycka, M.; Lu, Y.J.; Brown, R.A.; Lau, M.R.; Shipley, J.M.; Fry, M.J.
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
Genomics
54
569-574
1998
Homo sapiens (O75747), Homo sapiens
Manually annotated by BRENDA team
Ktori, C.; Shepherd, P.R.; O'Rourke, L.
TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase
Biochem. Biophys. Res. Commun.
306
139-143
2003
Mus musculus
Manually annotated by BRENDA team
Prior, I.A.; Clague, M.J.
Localization of a class II phosphatidylinositol 3-kinase, PI3KC2a, to clathrin-coated vesicles
Mol. Cell. Biol.
1
162-166
1999
Rattus norvegicus
Manually annotated by BRENDA team
Gaidarov, I.; Smith, M.E.K.; Domin, J.; Keen, J.H.
The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
Mol. Cell
7
443-449
2001
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Turner, S.J.; Domin, J.; Waterfield, M.D.; Ward, S.G.; Westwick, J.
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
J. Biol. Chem.
273
25987-25995
1998
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Domin, J.; Gaidarov, I.; Smith, M.E.K.; Keen, J.H.; Waterfield, M.D.
The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
J. Biol. Chem.
275
11943-11950
2000
Cricetulus griseus, Homo sapiens, Rattus norvegicus, Cricetulus griseus PI3K-C2alpha, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Wheeler, M.; Domin, J.
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2
Mol. Cell. Biol.
21
6660-6667
2001
Homo sapiens
Manually annotated by BRENDA team
El Sheikh, S.S.; Domin, J.; Tomtitchong, P.; Abel, P.; Stamp, G.; Lalani, E.N.
Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation
BMC Clin. Pathol.
3
4
2003
Homo sapiens
Manually annotated by BRENDA team
Shepherd, P.R.
Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
Acta Physiol. Scand.
183
3-12
2005
Homo sapiens (O00443), Mus musculus (Q61194), Homo sapiens PI3K-C2alpha (O00443)
Manually annotated by BRENDA team
Kang, S.; Song, J.; Kang, J.; Kang, H.; Lee, D.; Lee, Y.; Park, D.
Suppression of the alpha-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
Biochem. Biophys. Res. Commun.
329
6-10
2005
Homo sapiens (O00443)
Manually annotated by BRENDA team
Crljen, V.; Volinia, S.; Banfic, H.
Hepatocyte growth factor activates phosphoinositide 3-kinase C2beta in renal brush-border plasma membranes
Biochem. J.
365
791-799
2002
Rattus norvegicus
Manually annotated by BRENDA team
Arcaro, A.; Khanzada, U.K.; Vanhaesebroeck, B.; Tetley, T.D.; Waterfield, M.D.; Seckl, M.J.
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
EMBO J.
21
5097-5108
2002
Homo sapiens
Manually annotated by BRENDA team
MacDougall, L.K.; Gagou, M.E.; Leevers, S.J.; Hafen, E.; Waterfield, M.D.
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways
Mol. Cell. Biol.
24
796-808
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Sindic, A.; Crljen, V.; Matkovic, K.; Lukinovic-Skudar, V.; Visnjic, D.; Banfic, H.
Activation of phosphoinositide 3-kinase C2 beta in the nuclear matrix during compensatory liver growth
Adv. Enzyme Regul.
46
280-287
2006
Rattus norvegicus
Manually annotated by BRENDA team
Falasca, M.; Maffucci, T.
Role of class II phosphoinositide 3-kinase in cell signalling
Biochem. Soc. Trans.
35
211-214
2007
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Traer, C.J.; Foster, F.M.; Abraham, S.M.; Fry, M.J.
Are class II posphoinositide 3-kinases potential targets for anticancer therapies?
Bull. Cancer
93
E53-E58
2006
Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens (O75747)
Manually annotated by BRENDA team
Katso, R.M.; Pardo, O.E.; Palamidessi, A.; Franz, C.M.; Marinov, M.; De Laurentiis, A.; Downward, J.; Scita, G.; Ridley, A.J.; Waterfield, M.D.; Arcaro, A.
Phosphoinositide 3-kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
Mol. Biol. Cell
17
3729-3744
2006
Homo sapiens
Manually annotated by BRENDA team
Russo, A.; Okur, M.N.; Bosland, M.; OBryan, J.P.
Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2beta) isoform contributes to neuroblastoma tumorigenesis
Cancer Lett.
359
262-268
2015
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Aki, S.; Yoshioka, K.; Okamoto, Y.; Takuwa, N.; Takuwa, Y.
Phosphatidylinositol 3-kinase class II alpha-isoform PI3K-C2alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells
J. Biol. Chem.
290
6086-6105
2015
Homo sapiens (O00443)
Manually annotated by BRENDA team
Mountford, J.K.; Petitjean, C.; Putra, H.W.; McCafferty, J.A.; Setiabakti, N.M.; Lee, H.; T?nnesen, L.L.; McFadyen, J.D.; Schoenwaelder, S.M.; Eckly, A.; Gachet, C.; Ellis, S.; Voss, A.K.; Dickins, R.A.; Hamilton, J.R.; Jackson, S.P.
The class II PI 3-kinase, PI3KC2alpha, links platelet internal membrane structure to shear-dependent adhesive function
Nat. Commun.
6
6535
2015
Mus musculus (Q61194)
Manually annotated by BRENDA team
Chikh, A.; Ferro, R.; Abbott, J.J.; Pineiro, R.; Buus, R.; Iezzi, M.; Ricci, F.; Bergamaschi, D.; Ostano, P.; Chiorino, G.; Lattanzio, R.; Broggini, M.; Piantelli, M.; Maffucci, T.; Falasca, M.
Class II phosphoinositide 3-kinase C2alpha regulates a novel signaling pathway involved in breast cancer progression
Oncotarget
7
18325-18345
2016
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Nigorikawa, K.; Hazeki, K.; Guo, Y.; Hazeki, O.
Involvement of class II phosphoinositide 3-kinase ?-isoform in antigen-induced degranulation in RBL-2H3 cells.
PLoS ONE
9
e111698
2014
Rattus norvegicus
Manually annotated by BRENDA team
Mavrommati, I.; Cisse, O.; Falasca, M.; Maffucci, T.
Novel roles for class II phosphoinositide 3-kinase C2beta in signalling pathways involved in prostate cancer cell invasion
Sci. Rep.
6
23277
2016
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Yang, S.; Wu, Q.; Huang, S.; Wang, Z.; Qi, F.
Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase alpha subunit mediated vasoconstriction in rat aorta
BMC Anesthesiol.
16
63
2016
Rattus norvegicus (D3ZTF6)
Manually annotated by BRENDA team
Zhuo, M.Q.; Pan, Y.X.; Wu, K.; Xu, Y.H.; Luo, Z.
Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco
Gen. Comp. Endocrinol.
247
34-45
2017
Tachysurus fulvidraco (A0A2I4KAQ4), Tachysurus fulvidraco (A0A2I4KAQ7), Tachysurus fulvidraco
Manually annotated by BRENDA team
Falasca, M.; Hamilton, J.R.; Selvadurai, M.; Sundaram, K.; Adamska, A.; Thompson, P.E.
Class II phosphoinositide 3-kinases as novel drug targets
J. Med. Chem.
60
47-65
2017
Mus musculus (E9QAN8), Mus musculus (O70167), Mus musculus (Q61194), Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens (O75747)
Manually annotated by BRENDA team
Aung, K.T.; Yoshioka, K.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.
The class II phosphoinositide 3-kinases PI3K-C2alpha and PI3K-C2beta differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells
J. Physiol. Sci.
69
263-280
2019
Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team