2.6.1.52: phosphoserine transaminase
This is an abbreviated version!
For detailed information about phosphoserine transaminase, go to the full flat file.
Reaction
Synonyms
3-O-phospho-L-serine:2-oxoglutarate aminotransferase, 3-phosphoserine aminotransferase, AspAT, AtPSAT, AtPSAT1, BCIR PSAT, bmPSAT, EhPSAT, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, phosphoserine aminotransferase, phosphoserine aminotransferase 1, phosphoserine aminotransferase1, phosphoserine aminotransferase2, phosphoserine aminotransferases, PSAT, PSAT alpha, PSAT beta, PSAT-BALC, PSAT-BCIRA, PSAT-ECOLI, PSAT1, PSAT2, PSerAT, serC, sll1559
ECTree
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Inhibitors
Inhibitors on EC 2.6.1.52 - phosphoserine transaminase
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Aminooxyacetate
AOA, the transaminase inhibitor represses cell growth in a TAZ/YAP-dependent manner
chloride
the chloride ion in EhPSAT becomes trapped in the space between residues Gly99, Val 100, Ile 149, Thr 148, and Asn 147. The halide-binding site in close proximity to the active site is detected. A stretch of six amino acids (146-NNTIYG-151) only conserved in the Entamoeba genus, contributes to halide binding. Structure comparisons, overview
additional information
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not inhibitory: chloride, fluoride and bromide up to 200 mM
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