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2.6.1.36: L-lysine 6-transaminase

This is an abbreviated version!
For detailed information about L-lysine 6-transaminase, go to the full flat file.

Word Map on EC 2.6.1.36

Reaction

L-lysine
+
2-oxoglutarate
=
(S)-2-amino-6-oxohexanoate
 +
L-glutamate

Synonyms

aminotransferase, lysine 6-, EC 2.6.1.68, L-lysine-alpha-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, L-lysine-epsilon-aminotransferase, LAT, lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine-epsilon-aminotransferase, lysine:2-ketoglutarate 6-aminotransferase, Rv3290c

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.36 L-lysine 6-transaminase

Substrates Products

Substrates Products on EC 2.6.1.36 - L-lysine 6-transaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-N-acetyl-L-ornithine + 2-oxoglutarate
5-(N-acetylamino)-2-oxopentanoate + L-glutamate
show the reaction diagram
-
4.0% of the activity with L-lysine
-
-
?
6-N-acetyl-L-lysine + 2-oxoglutarate
6-(N-acetylamino)-2-oxohexanoate + L-glutamate
show the reaction diagram
-
5.7% of the activity with L-lysine
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
-
very slow
-
-
?
L-lysine + 2-oxoadipate
2-aminoadipate 6-semialdehyde + L-homoglutarate
show the reaction diagram
-
7% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxobutanoate
2-aminoadipate 6-semialdehyde + 2-aminobutanoate
show the reaction diagram
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
show the reaction diagram
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + 1-piperideine-6-carboxylic acid + L-glutamate
show the reaction diagram
Q5XPV2
-
product 2-aminoadipate 6-semialdehyde is further transformed to 1-piperideine-6-carboxylic acid, which may react with methylglyoxal to generate the acylated N-heterocyclic odorant 2-acetyltetrahydropyridine
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + ?
show the reaction diagram
Q5XPV2
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
show the reaction diagram
L-lysine + 2-oxohexanoate
2-aminoadipate 6-semialdehyde + 2-aminohexanoate
show the reaction diagram
-
8.7% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxopentanoate
2-aminoadipate 6-semialdehyde + 2-aminopentanoate
show the reaction diagram
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
show the reaction diagram
L-lysine + pyruvate
2-aminoadipate 6-semialdehyde + L-alanine
show the reaction diagram
L-lysine hydroxamate + 2-oxoglutarate
? + L-glutamate
show the reaction diagram
-
5.1% of the activity with L-lysine
-
-
?
L-ornithine + 2-oxoglutarate
5-hydroxy-L-proline + glutamate
show the reaction diagram
L-ornithine + 2-oxoglutarate
? + L-glutamate
show the reaction diagram
L-thialysine + 2-oxoglutarate
? + L-glutamate
show the reaction diagram
-
13% of the activity with L-lysine
-
-
?
N-alpha-benzyloxycarbonyl-L-ornithine + 2-oxoglutarate
N-benzyloxycarbonyl-5-hydroxy-L-proline + glutamate
show the reaction diagram
N-alpha-tert-butoxycarbonyl-L-ornithine + 2-oxoglutarate
N-tert-butoxycarbonyl-5-hydroxy-L-proline + glutamate
show the reaction diagram
S-(2-aminoethyl)-L-cysteine + 2-oxoglutarate
? + L-glutamate
show the reaction diagram
S-(2-N-acetylaminoethyl)-L-cysteine + 2-oxoglutarate
S-(2-N-acetylaminoethyl)-2-oxopropanoic acid + L-glutamate
show the reaction diagram
-
3.3% of the activity with L-lysine
-
-
?
additional information
?
-