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2.6.1.36: L-lysine 6-transaminase

This is an abbreviated version!
For detailed information about L-lysine 6-transaminase, go to the full flat file.

Word Map on EC 2.6.1.36

Reaction

L-lysine
+
2-oxoglutarate
=
(S)-2-amino-6-oxohexanoate
 +
L-glutamate

Synonyms

aminotransferase, lysine 6-, EC 2.6.1.68, L-lysine-alpha-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, L-lysine-epsilon-aminotransferase, LAT, lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine-epsilon-aminotransferase, lysine:2-ketoglutarate 6-aminotransferase, Rv3290c

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.36 L-lysine 6-transaminase

Crystallization

Crystallization on EC 2.6.1.36 - L-lysine 6-transaminase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
docking experiments based on crystal structure PDB code 2CJH in order to identify enzyme inhibitors
hanging drop vapour diffusion method in 0.1 M trisodium citrate dihydrate solution containing 0.2 M ammonium acetate and 25% PEG 4000 in the pH range 5.4-6.0
-
molecular docking of inhibitors 4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide. Ligands are found in the vicinity of the Arg422, Gln274, Lys300, Arg170, Phe167, Glu243 amino acid residues. Compounds can make favourable interactions with important amino acid residues such as Arg170, Arg440, and Lys300
strcutures of mutants T330S, E243A, N328A, to 2.7-1.95 A resolution