2.6.1.36: L-lysine 6-transaminase

This is an abbreviated version!
For detailed information about L-lysine 6-transaminase, go to the full flat file.

Reaction

Synonyms

aminotransferase, lysine 6-, EC 2.6.1.68, L-lysine-alpha-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, L-lysine-epsilon-aminotransferase, LAT, lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine-epsilon-aminotransferase, lysine:2-ketoglutarate 6-aminotransferase, Rv3290c

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.36 L-lysine 6-transaminase

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Results	in table
6	Activating Compound
2110	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
14	Cofactor
7	Crystallization (Commentary)
2	Expression
7	General Information
1	General Stability
27	IC50 Value
43	Inhibitors
18	KM Value [mM]
19	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
254	Organism
3	Pathway
8	PDB ID
10	pH Optimum
3	pH Range
1	pH Stability
9	Protein Variants
11	Purification (Commentary)
3	Reaction
2	Reaction Type
39	Reference
8	Specific Activity [micromol/min/mg]
1	Storage Stability
73	Substrates and Products (Substrate)
8	Subunits
33	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
6	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.6.1.36 - L-lysine 6-transaminase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.05378

(E)-2-(2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00308

(E)-2-(4-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.03791

(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-indol-3-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.01705

(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-pyrrol -2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.02319

(E)-2-(benzo[d]thiazol-2-yl)-3-(2,4-dihydroxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.06489

(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.06141

(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.04793

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-benzyloxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00411

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-fluorophenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00783

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.01038

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxyphenyl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.01959

(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrofuran-2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.05476

(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.01623

(E)-2-(benzo[d]thiazol-2-yl)-3-(furan-2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.09257

(E)-2-(benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00374

(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00573

(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.06598

(E)-3-(benzo[d][1,3]dioxol-5-yl)-2-(benzo[d]thiazol-2-yl)acrylonitrile

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.01406

(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00672

(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00262

(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)isophthalic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00115

(E)-5-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)isophthalic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

758905

0.00081

2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide]

Mycobacterium tuberculosis

P9WQ77

pH not specified in the publication, temperature not specified in the publication

738029

0.0019

2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide]

Mycobacterium tuberculosis

P9WQ77

pH not specified in the publication, temperature not specified in the publication

738029

0.0018

2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

739738

0.0017

4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

739738

0.0012

4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid

Mycobacterium tuberculosis

P9WQ77

pH 7.2, 37°C

739738